TY - JOUR T1 - Prognostic Value of Total Lesion Glycolysis by <sup>18</sup>F-FDG PET/CT in Surgically Resected Stage IA Non–Small Cell Lung Cancer JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 45 LP - 49 DO - 10.2967/jnumed.114.147561 VL - 56 IS - 1 AU - Seong Yong Park AU - Arthur Cho AU - Woo Sik Yu AU - Chang Young Lee AU - Jin Gu Lee AU - Dae Joon Kim AU - Kyung Young Chung Y1 - 2015/01/01 UR - http://jnm.snmjournals.org/content/56/1/45.abstract N2 - Despite the favorable prognosis of stage IA non–small cell lung cancer (NSCLC), the disease recurs after complete surgical resection in 20%–30% of patients. This study determined the prognostic value of various metabolic parameters of 18F-FDG PET/CT in surgically resected stage IA NSCLC. Methods: We retrospectively reviewed 248 patients with stage IA NSCLC who underwent lobectomy and complete lymph node dissection after PET/CT. A region of interest was drawn on the primary lesion, and metabolic indices such as metabolic tumor volume, maximum standardized uptake value (SUVmax), and total lesion glycolysis (TLG) were measured using an SUV cutoff of 2.5. Results: The patients included 134 men and 114 women, and the mean age was 63.03 ± 10.01 y; 129 were stage T1a (≤2 cm) and 119 were T1b (&gt;2 cm). The median follow-up period was 36.6 mo. Recurrence took place in 15 patients. The mean (±SD) SUVmax, metabolic tumor volume, and TLG were 4.55 ± 3.75, 5.92 ± 5.57, and 14.42 ± 17.35, respectively. The cutoffs of SUVmax and TLG were 3.7 and 13.76, respectively. The 5-y overall survival (OS) was 95.1% in low-SUVmax patients and 82.2% in high-SUVmax patients (P = 0.02). The 5-y OS was 93.7% in low-TLG patients and 78.3% in high-TLG patients (P = 0.01). On multivariate analysis, TLG was a risk factor for OS (hazard ratio, 3.159; P = 0.040), but SUVmax showed marginal significance (P = 0.064). The concordance index of the TLG model was 0.676 (95% CI, 0.541–0.812). Conclusion: TLG was a significant prognostic factor for OS in patients with stage IA NSCLC. ER -