TY - JOUR T1 - The correlation between the level of <sup>99</sup>Tc<sup>m</sup>N-NOET uptake by pulmonary nodules with long-term prognostic value in patients with lung cancer JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1378 LP - 1378 VL - 56 IS - supplement 3 AU - Hai-yan Liu AU - Si-jin Li AU - Zhi-fang Wu AU - Jian-zhong Liu AU - Hua Wei AU - Yan Cheng AU - Xiao-shan Guo Y1 - 2015/05/01 UR - http://jnm.snmjournals.org/content/56/supplement_3/1378.abstract N2 - 1378 Objectives To assess the correlation between the level of 99TcmN-NOET uptake by pulmonary nodules with long-term prognostic value in patients with lung cancer.Methods Fifty-one patients (37 men, mean age 57 ± 9 years) with primary malignancy of lung underwent CT, early and delay 99TcmN-NOET dual-phase SPECT before operated. All patients completed clinical follow-up regarding poor prognosis (recurrence and metastasis, death) for a mean period of 84 ±6 months.Results Poor prognosis rates were analysed in subgroups defined according to the presence of the value of early T/N ratio (ER),delayed T/N ratio (DR) and the retention index (RI%).During the follow-up, 9 deaths were recorded, 13 of lymph node metastases, 7 of other soft tissues metastases, 7 of bone metastases. The high risk for poor prognosis was associated with the presence of accumulate NOET of all analysed end points: early 99TcmN-NOET SPECT by lung nodules (HR = 2.76,P =0.01), delayed 99TcmN-NOET SPECT(HR =2.66, P = 0.001), the retention index(HR =2.55,P = 0·001), tumor diameter(HR =1.66, P = 0.06), liquefaction necrosis(HR =1.58, P =0.08).Conclusions The more accumulate of NOET was associated with poor prognosis in patients of lung cancer. In long-term follow-up, 99TcmN-NOET SPECT proved highly predictive of poor prognosis in patients with lung cancer.Research Support The fund of basic research project of Shanxi Province(2012021030-2) The fund of science and technology innovation projects of Shanxi province colleges and universities(20141101) The fund of youth innovation of Shanxi medical university(01201415) The relationship between poor prognosis with quantitative data of 99TcmN-NOET dual-phase SPECTHR means hazard ratio. ER -