TY - JOUR T1 - Castration-Resistant Prostate Cancer Bone Metastasis Response Measured by <sup>18</sup>F-Fluoride PET After Treatment with Dasatinib and Correlation with Progression-Free Survival: Results from American College of Radiology Imaging Network 6687 JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 354 LP - 360 DO - 10.2967/jnumed.114.146936 VL - 56 IS - 3 AU - Evan Y. Yu AU - Fenghai Duan AU - Mark Muzi AU - Xuan Deng AU - Bennett B. Chin AU - Joshi J. Alumkal AU - Mary-Ellen Taplin AU - Jina M. Taub AU - Ben Herman AU - Celestia S. Higano AU - Robert K. Doot AU - Donna Hartfeil AU - Philip G. Febbo AU - David A. Mankoff Y1 - 2015/03/01 UR - http://jnm.snmjournals.org/content/56/3/354.abstract N2 - 18F-fluoride PET quantitatively images bone metabolism and may serve as a pharmacodynamic assessment for systemic therapy such as dasatinib, a potent SRC kinase inhibitor, with activity in bone. Methods: This was an imaging companion trial (American College of Radiology Imaging Network [ACRIN] 6687) to a multicenter metastatic castration-resistant prostate cancer (CRPC) tissue biomarker–guided therapeutic trial (NCT00918385). Men with bone metastatic CRPC underwent 18F-fluoride PET before and 12 weeks after initiation of dasatinib (100 mg daily). Dynamic imaging was performed over a 15-cm field of view for trial assessments. The primary endpoint was to determine whether changes in 18F-fluoride incorporation in tumor and normal bone occurred in response to dasatinib. Other endpoints included differential effect of dasatinib between 18F-fluoride incorporation in tumor and normal bone, 18F-fluoride transport in bone metastases, correlation with progression-free survival (PFS), prostate-specific antigen, and markers of bone turnover. Results: Eighteen participants enrolled, and 17 underwent interpretable baseline 18F-fluoride PET imaging before initiation of dasatinib. Twelve of 17 patients underwent on-treatment PET imaging. Statistically significant changes in response to dasatinib were identified by the SUVmaxavg (average of maximum standardized uptake value [SUVmax] for up to 5 tumors within the dynamic field of view) in bone metastases (P = 0.0002), with a significant differential 18F-fluoride PET response between tumor and normal bone (P &lt; 0.0001). Changes in 18F-fluoride incorporation in bone metastases had borderline correlation with PFS by SUVmaxavg (hazard ratio, 0.91; 95% confidence interval, 0.82–1.00; P = 0.056). Changes by SUVmaxavg correlated with bone alkaline phosphatase (P = 0.0014) but not prostate-specific antigen (P = 0.47). Conclusion: This trial provides evidence of the ability 18F-fluoride PET to delineate treatment response of dasatinib in CRPC bone metastases with borderline correlation with PFS. ER -