PT - JOURNAL ARTICLE AU - François Bénard AU - Stefan K. Zeisler AU - Milan Vuckovic AU - Kuo-Shyan Lin AU - Zhengxing Zhang AU - Nadine Colpo AU - Xinchi Hou AU - Thomas J. Ruth AU - Paul Schaffer TI - Cross-Linked Polyethylene Glycol Beads to Separate <sup>99m</sup>Tc-Pertechnetate from Low-Specific-Activity Molybdenum AID - 10.2967/jnumed.114.143834 DP - 2014 Nov 01 TA - Journal of Nuclear Medicine PG - 1910--1914 VI - 55 IP - 11 4099 - http://jnm.snmjournals.org/content/55/11/1910.short 4100 - http://jnm.snmjournals.org/content/55/11/1910.full SO - J Nucl Med2014 Nov 01; 55 AB - We report a kit-based approach for the purification of sodium pertechnetate (99mTcO4−) from solutions with high MoO42− content. Methods: Cross-linked polyethylene glycol resins (ChemMatrix) were used to separate 99mTc and molybdenum in 4N NaOH. The resins were loaded at various flow rates and eluted with water to release 99mTc. The 99mTc solution was passed through a cation exchange resin and an alumina cartridge, followed by saline elution. This process was tested with cyclotron-produced 99mTc using an automated system and disposable kits. Results: Optimal results were obtained by loading 500 mg of resin at flow rates of up to 3.1 mL/min, with quantitative extraction of 99mTc from the molybdate solution and complete release of 99mTc after elution with water. The automated system was highly efficient at isolating Na99mTcO4 within minutes, with a recovery rate of 92.7% ± 1.1% (mean ± SD) using cyclotron-produced 99mTc. Conclusion: ChemMatrix resins were highly effective at separating 99mTcO4− from molybdate solutions.