@article {Jentzen1759, author = {Walter Jentzen and Jan Hoppenbrouwers and Paul van Leeuwen and Daan van der Velden and Rudie van de Kolk and Thorsten Dirk Poeppel and James Nagarajah and Wolfgang Brandau and Andreas Bockisch and Sandra Rosenbaum-Krumme}, title = {Assessment of Lesion Response in the Initial Radioiodine Treatment of Differentiated Thyroid Cancer Using 124I PET Imaging}, volume = {55}, number = {11}, pages = {1759--1765}, year = {2014}, doi = {10.2967/jnumed.114.144089}, publisher = {Society of Nuclear Medicine}, abstract = {124I PET/CT images from differentiated thyroid cancer patients were retrospectively analyzed to assess the relationship between absorbed radiation dose (AD) to lesions and their response after radioiodine therapy. Methods: Patients received serial 124I PET/CT scans before and after their first radioiodine treatment. The pretherapy PET data were used to segment the lesion volumes and to predict the therapy-delivered ADs after administration of the therapeutic 131I activity. The segmentation method{\textquoteright}s lower volume limit of determinability was a sphere of 0.80 mL, which classified the lesions into a known-volume group (\>0.80 mL) or a small-volume group (<=0.80 mL) with their respective average and minimum ADs. The posttherapy PET data were used to assess the lesion-based therapy success. In the known-volume group, the response rate was calculated on the basis of lesions that received average ADs above the generally accepted threshold of 85 Gy for metastases and 300 Gy for thyroid remnants (TRs) and was expressed as the percentage of completely responding lesions. In the small-volume group, the metastasis and TR responses were evaluated for 3 minimum-AD groups: 5 to 10 Gy (TR, 5 to 30 Gy), \>10 to 85 Gy (TR, \>30 to 300 Gy), and \>85 Gy (TR, \>300 Gy). Their response rates were calculated in terms of the percentage of completely responding lesions in each minimum-AD group. Results: In total, 59 lesions in 17 patients were amenable to reliable volume estimation. The response rates were 63\%, 88\%, and 90\% for lymph node metastases (LMs), pulmonary metastases, and TRs, respectively. The response rates of 168 small lesions in 34 patients were more than 82\% for LMs and more than 91\% for TRs in each of the 3 minimum-AD groups; all small pulmonary metastases responded completely. Conclusion: In the known-volume group, the response rate for TRs matched well with historical data derived using 131I scintigraphy imaging, whereas the response rate for LMs was not as high as expected, which may be explained by too short a follow-up time for a few LMs and a higher sensitivity of PET imaging. Small lesions were treated effectively, suggesting that they are considerably smaller than 0.80 mL.}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/55/11/1759}, eprint = {https://jnm.snmjournals.org/content/55/11/1759.full.pdf}, journal = {Journal of Nuclear Medicine} }