PT  - JOURNAL ARTICLE
AU  - Erwin, William
AU  - Jessop, Aaron
AU  - Peirsol, Wade
AU  - Mar, Martha
AU  - Jones, Scottie
AU  - Macapinlac, Homer
AU  - Mawlawi, Osama
TI  - Qualitative and quantitative comparison of gated blood pool SPECT using low-energy high-resolution and SMARTZOOM collimation
DP  - 2014 May 01
TA  - Journal of Nuclear Medicine
PG  - 1736--1736
VI  - 55
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/55/supplement_1/1736.short
4100  - http://jnm.snmjournals.org/content/55/supplement_1/1736.full
SO  - J Nucl Med2014 May 01; 55
AB  - 1736 Objectives To compare gated blood pool (MUGA) SPECT image quality between Siemens IQ•SPECT (SMARTZOOM collimator, Flash 3D OSEM) and low-energy high-resolution (LEHR) collimator SPECT with either Flash 3D or filtered backprojection (FBP) reconstruction, and SPECT ejection fraction (EF) to planar, under conditions of decreased scan time (ST) and/or injected activity (IA). Methods Routine planar MUGA scanning, followed by LEHR and IQ•SPECT in succession, was performed on 10 patients. 16-bin IQ• and LEHR MUGA SPECT scans were acquired on a Siemens dual-head Symbia® T6 SPECT/CT scanner, using: a 128×128 matrix (4.8 mm/pixel); a non-circular orbit (208° and 180°, respectively); 17 and 32 views/head, respectively; and total acquisition time equivalent to our 26-min, two-view 24-bin planar MUGA exam. Six “back and forth” 4-min scans were summed into 4, 8, 12, 16, 20 and 24 min ST scans, and reconstructed using Flash 3D (IQ•SPECT: 20 it, 3 ss; and LEHR: 8 it, 8ss, 9.6 mm Gaussian) and FBP (LEHR: Butterworth 0.45 Nyquist/7th order). No attenuation correction was applied (not supported for gated SPECT). Image quality (uniformity, contrast, and wall motion) was assessed qualitatively by a NM physician. SPECT (Cedars QBS) left ventricular EF was compared with planar. Results Visual inspection showed that IQ•SPECT for all STs consistently had the best contrast, uniformity, and wall motion. Furthermore, IQ•SPECT ST of 4, 8 and 16 min had similar image quality to 24-min LEHR FBP, Flash 3D and planar, respectively. The average EF correlations over all STs between IQ•SPECT, LEHR+FLASH and LEHR+FBP vs. planar were 0.68, 0.71 and 0.62, respectively. Only IQ•SPECT correlation improved vs. ST. All were statistically significant (p<0.05) except for LEHR+FBP 16-min and 20-min vs. planar. Conclusions IQ•SPECT visual interpretation is equivalent to or better than planar MUGA at up to a 33% decrease in ST or IA. SPECT EF is higher but correlated to planar. Research Support Siemens Medical Solutions USA, Inc.