PT  - JOURNAL ARTICLE
AU  - Ohshima, Satoru
AU  - Nishio, Masami
AU  - Kojima, Akihiro
AU  - Tamai, Shin-ichi
AU  - Tkobyashi, Toshiki
AU  - Sakakibara, Takashi
AU  - Kamoi, Daisuke
AU  - Aoyama, Toru
AU  - Hori, Hiroshi
AU  - Murohara, Toyoaki
TI  - Myocardial microvascular dysfunction in chronic kidney disease and hemodialysis patients evaluated by pharmacological stress 13N-ammonia positron emission tomography myocardial perfusion imaging
DP  - 2014 May 01
TA  - Journal of Nuclear Medicine
PG  - 1729--1729
VI  - 55
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/55/supplement_1/1729.short
4100  - http://jnm.snmjournals.org/content/55/supplement_1/1729.full
SO  - J Nucl Med2014 May 01; 55
AB  - 1729 Objectives We investigated myocardial blood flow (MBF) and coronary flow reserve (CFR) evaluated by 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI) in chronic kidney disease (CKD) and hemodialysis patient. Methods MBF was evaluated at rest and ATP induced hyperemia, and CFR was calculated by 13N-ammonia PET MPI. Twenty hemodialysis (HD) patients, 10 CKD (eGFR < 60 mL/min/m2) patients without HD, and 17 non-CKD patients without perfusion defect (SSS < 3) were investigated. Results Rest MBF was significantly increased in HD patients than CKD or non-CKD patients. No significant differences between each study group in stress MBF. CFR were significantly impaired in CKD and HD patient than non-CKD patient. No significant correlations between each parameter and hemoglobin or blood pressure were observed. Conclusions Impaired CFR and increased rest MBF were observed in hemodialysis and CKD patient evaluated by pharmacological stress 13N-ammonia PET MPI.