PT  - JOURNAL ARTICLE
AU  - Abhishek Sharma
AU  - Ashwani Sood
AU  - Bhagwant Mittal
AU  - Uttam Mete
AU  - Nandita Kakkar
TI  - Correlation of SUVmax during early dynamic and post diuretic 18F FDG PET/CT with grade and T stage of bladder tumors
DP  - 2014 May 01
TA  - Journal of Nuclear Medicine
PG  - 1672--1672
VI  - 55
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/55/supplement_1/1672.short
4100  - http://jnm.snmjournals.org/content/55/supplement_1/1672.full
SO  - J Nucl Med2014 May 01; 55
AB  - 1672 Objectives To investigate whether there exits any correlation between SUVmax during early dynamic and post diuretic 18F FDG PET/CT and the grade and T stage of bladder cancer. Methods A total of 39 patients with suspected or proven bladder carcinoma underwent 18F-FDG PET/CT early dynamic imaging of the pelvis consisting of a series of 5 dynamic scans of 2 minutes starting at the time of injection and delayed images of the whole body after diuresis and controlled IV hydration at 60 minutes post injection. The SUVmax of the bladder tumors both during the early dynamic and post diuretic FDG PET/CT were compared to the grade and T stage of the bladder tumors as ascertained from the histopathology. Results During the early dynamic images bladder tumors showed a trend of high FDG uptake in the high grade as compared to low grade bladder tumors (mean SUVmax at 2 minutes 5.43±1.45 vs 4.65±1.60, p = 0.14). Whereas in the post diuretic PET/CT the mean SUVmax of the high grade bladder tumors was lower as compared to the low grade tumors (mean SUVmax 16.1±11.6 vs 20.7±11.7, p = 0.26). Non-invasive stage Ta bladder tumors (2 patients) showed significantly lower mean SUVmax (3.3±2.6, p = 0.001) than other T-stage bladder tumors (5.5±1.4) at 2 minute of dynamic imaging. Stage Ta, T1, T2, T3 and T4 bladder tumors did not show any significant difference in the mean SUVmax at 10 minutes of dynamic imaging and in post diuretic FDG PET/CT. Conclusions Although SUVmax of the high bladder tumors was higher in the early dynamic imaging but it was not statistically significant and as such SUVmax values during early dynamic as well as post diuretic PET/CT are not a reliable indicator of the Grade of bladder tumors. The mean SUVmax of Stage Ta was significantly less than other T stage tumors however further studies are required to see if this trend is seen with a larger number of patients.