RT Journal Article
SR Electronic
T1 NUKDOS: A software tool for dosimetry prior to molecular radiotherapy
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1128
OP 1128
VO 55
IS supplement 1
A1 Kletting, Peter
A1 Schimmel, Sebastian
A1 Haenscheid, Heribert
A1 Fernandez, Maria
A1 Bröer, Jörn
A1 Luster, Markus
A1 Nosske, Dietmar
A1 Lassmann, Michael
A1 Glatting, Gerhard
YR 2014
UL http://jnm.snmjournals.org/content/55/supplement_1/1128.abstract
AB 1128 Objectives The aim of this work is the development of a dosimetry software tool for molecular radiotherapy. The software should include all relevant methods for calculating the activity to administer and the pertaining absorbed doses (with the corresponding error) using imaging or counter data as input. Methods NUKDOS was developed in MATLAB and follows the MIRD formalism on a voxel-level. Tools for image and counter data processing as well as modelling, fitting and therapy planning are included. All required steps for dosimetry in molecular radiotherapy can be conducted based on a series of planar gamma camera images and one SPECT/CT. The error of the absorbed doses is estimated by Gaussian error propagation taking into account the errors of each step. In addition, NUKDOS supports the latest EANM SOP formalism provided for dosimetry in the treatment of thyroid diseases. To demonstrate and validate NUKDOS, the results of dosimetry in receptor radionuclide therapy and in the treatment of thyroid diseases were compared to the output of other software (OLINDA/EXM, SAAM2 and UlmDOS). Results NUKDOS and UlmDos yielded very similar time-activity curves taking into account the problem of drawing the same ROI with different software tools. The fitting results (based on the same data) of SAAM 2 were identical. Using the same time-integrated activity coefficients in OLINDA/EXM (mass corrected), produced differences < 5% for the activity to administer. Conclusions NUKDOS can be applied for dosimetry prior to molecular radiotherapy using a series of gamma camera images and one SPECT/CT (PET/CT) as well as counter data. The implemented methodology allows the objective estimate of the activity to administer and the pertaining absorbed doses with the corresponding error.