PT  - JOURNAL ARTICLE
AU  - Kletting, Peter
AU  - Schimmel, Sebastian
AU  - Haenscheid, Heribert
AU  - Fernandez, Maria
AU  - Bröer, Jörn
AU  - Luster, Markus
AU  - Nosske, Dietmar
AU  - Lassmann, Michael
AU  - Glatting, Gerhard
TI  - NUKDOS: A software tool for dosimetry prior to molecular radiotherapy
DP  - 2014 May 01
TA  - Journal of Nuclear Medicine
PG  - 1128--1128
VI  - 55
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/55/supplement_1/1128.short
4100  - http://jnm.snmjournals.org/content/55/supplement_1/1128.full
SO  - J Nucl Med2014 May 01; 55
AB  - 1128 Objectives The aim of this work is the development of a dosimetry software tool for molecular radiotherapy. The software should include all relevant methods for calculating the activity to administer and the pertaining absorbed doses (with the corresponding error) using imaging or counter data as input. Methods NUKDOS was developed in MATLAB and follows the MIRD formalism on a voxel-level. Tools for image and counter data processing as well as modelling, fitting and therapy planning are included. All required steps for dosimetry in molecular radiotherapy can be conducted based on a series of planar gamma camera images and one SPECT/CT. The error of the absorbed doses is estimated by Gaussian error propagation taking into account the errors of each step. In addition, NUKDOS supports the latest EANM SOP formalism provided for dosimetry in the treatment of thyroid diseases. To demonstrate and validate NUKDOS, the results of dosimetry in receptor radionuclide therapy and in the treatment of thyroid diseases were compared to the output of other software (OLINDA/EXM, SAAM2 and UlmDOS). Results NUKDOS and UlmDos yielded very similar time-activity curves taking into account the problem of drawing the same ROI with different software tools. The fitting results (based on the same data) of SAAM 2 were identical. Using the same time-integrated activity coefficients in OLINDA/EXM (mass corrected), produced differences < 5% for the activity to administer. Conclusions NUKDOS can be applied for dosimetry prior to molecular radiotherapy using a series of gamma camera images and one SPECT/CT (PET/CT) as well as counter data. The implemented methodology allows the objective estimate of the activity to administer and the pertaining absorbed doses with the corresponding error.