PT  - JOURNAL ARTICLE
AU  - Son, Seung Hyun
AU  - Kang, Sungmin
AU  - Jung, Ji-hoon
AU  - Kim, Choon-Young
AU  - Kim, Do-Hoon
AU  - Hong, Chae Moon
AU  - Jeong, Shin Young
AU  - Lee, Sang-Woo
AU  - Ahn, Byeong-Cheol
AU  - Lee, Jaetae
TI  - Total lesion glycolysis by <sup>18</sup>F-FDG PET/CT is a reliable predictor of recurrence in cutaneous malignant melanoma
DP  - 2014 May 01
TA  - Journal of Nuclear Medicine
PG  - 1684--1684
VI  - 55
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/55/supplement_1/1684.short
4100  - http://jnm.snmjournals.org/content/55/supplement_1/1684.full
SO  - J Nucl Med2014 May 01; 55
AB  - 1684 Objectives This study was performed to evaluate the prognostic relevance of total lesion glycolysis (TLG) measured by F-18 FDG PET/CT in patients with primary cutaneous malignant melanoma (CMM). Methods This is a retrospective review (Mar 2005 to Nov 2010) of forty-three patients with histologic diagnosis of CMM who underwent pretreatment F-18 FDG PET/CT. PET parameters [SUVmax, metabolic tumor volume (MTV, cm3) and total lesion glycolysis (TLG)] of primary tumor were measured. Clinical variables such as age, sex, clinical stage, and location and thickness of primary lesion, and existence of ulceration were also assessed. Univariate and multivariate analyses for disease free survival (DFS) were performed by Kaplan-Meier method and Cox proportional hazards models. Results SUVmax, MTV, and TLG were found to be significantly higher in patients with recurrence (4.5 ± 2.9; 4.6 ± 3.8; 9.8 ± 8.7) than patients without recurrence (2.1 ± 1.6; 2.8 ± 1.5; 3.8 ± 3.3, p<0.001). The optimal cut-off values for the DFS determined using a receiver-operating characteristic (ROC) curve were 1.7 for SUVmax, 2.84 for TLG, however, MTV was not statistically significant on ROC curve analysis. The DFS rate among the 43 patients was 72%. On univariate analysis, ulceration of primary lesion (p = 0.004), stage ≥ III (p = 0.017), SUVmax > 1.7 (p = 0.001), and TLG > 2.84 (p = 0.005) affected the DFS, whereas others (age, sex, primary lesion site, and thickness of primary lesion) did not. However, none of them was statistically significant on multivariate analysis. Conclusions SUVmax and TLG of primary lesion on pretreatment F-18 FDG PET/CT significantly affected outcome in CMM patients. TLG could be used as a good surrogate marker for the prediction of DFS in CMM patients.