RT Journal Article
SR Electronic
T1 Performance comparison between NeuroPET-CT and Siemens ECAT HR+: NEMA and patient studies
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 2162
OP 2162
VO 55
IS supplement 1
A1 Ouyang, Jinsong
A1 Toole, Terry
A1 Keeler, Matthew
A1 Grogg, Kira
A1 Zhu, Xuping
A1 Li, Quanzheng
A1 Petibon, Yoann
A1 Normandin, Marc
A1 Alpert, Nathaniel
A1 El Fakhri, Georges
YR 2014
UL http://jnm.snmjournals.org/content/55/supplement_1/2162.abstract
AB 2162 Objectives The newly developed mobile NeuroPET-CT scanner is a dedicated high-resolution, high-sensitivity brain PET-CT. There has been significant hardware and software development since we first reported NEMA performance, as well as extensive clinical use. We report on performance of the NeuroPET-CT in phantom and clinical studies and compare to Siemens ECAT HR+. Methods NeuroPET-CT has been extensively used in 100+ patient studies at MGH. It appears that best image quality for patient studies can be achieved using a clinical setting, which has a coincidence timing window of 7 ns, 400-650 keV energy window, and half axial field of view (FOV) maximum ring difference. Sensitivity and noise equivalent count (NEC) rate have been re-measured based on the procedures of NEMA PET standard for the default clinical setting. For one patient FDG study, the HR+ image volume was registered to the NeuroPET image volume using rigid registration. The contrast (signal/background) in the caudate nucleus and putamen was computed for each scanner. Results The measured sensitivity, normalized to the activity placed in the 70 cm tube, was 0.79%, 0.83%, and 0.93% for r=0, 5, and 10 cm, respectively. The sensitivity was 24% (r=0) greater than the HR+ sensitivity. The peak NEC rate was 20.6 kHz measured at 2.86 kBq/ml. The FDG patient study shows that NeuroPET-CT yielded 17% higher contrast than HR+ in the caudate nucleus and putamen. Conclusions NeuroPET-CT was found to have higher spatial resolution, sensitivity, and NEC rate (at low activity level) than HR+. FDG patient studies also show that NeuroPET-CT yields better PET image quality than HR+.