RT Journal Article
SR Electronic
T1 Detection of prostate cancer (PCa) recurrence with 18F-fluorocholine (FCH) PET/CT in relation to Gleason score (GS) of primary tumor: Experience on 1,000 patients (pts)
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 398
OP 398
VO 55
IS supplement 1
A1 Evangelista, Laura
A1 Baseric, Tania
A1 Cimitan, Marino
A1 Bodanza, Valentina
A1 Hodolic, Marina
A1 Saladini, Giorgio
A1 Cervino, Anna
A1 Gregianin, Michele
A1 Fettich, Jurij
A1 Borsatti, Eugenio
YR 2014
UL http://jnm.snmjournals.org/content/55/supplement_1/398.abstract
AB 398 Objectives To explore the ability of GS to predict the detection rate of FCH PET/CT in recurrent PCa at any PSA levels, in a large cohort of pts. Methods FCH PET/CTs of 1030pts with biochemical relapse of PCa were reviewed from three institutes’ databases. 265 pts had GS <7, 330 had GS=7 and 435 had GS>7. PSA levels were ≤1, 1>PSA<2 and ≥2 in 299, 139 and in 592 pts, respectively. All pts had a PET/CT scan at 45-60 minutes after injection of 3-3.5 MBq/kg of FCH (IASOcholine, Austria). Continuous data were compared by t-Student test and categorical variables by chi-square test. Univariate and multivariate analysis were computed. Results 630 (61%) pts showed positive FCH PET/CTs for PCa recurrence. Local relapses were in 272 cases, lymph nodes metastases in 292 and distant metastases in 323. Positive PET/CTs were detected in 81% of pts with a PSA≥2, in 44% with 1>PSA<2 and in 30%with PSA≤1. At the same time, positive PET/CTs were in 51%, 30% and 19% of pts with GS>7, GS=7 and GS<7, respectively. Negative FCH PET/CTs were detected in 343 (33.3%) pts: 189 with a PSA≤1, 65 with a 1>PSA<2, 89 with a PSA≥2. Among pts with negative FCH scans, 36% had GS<7, more 36% had GS=7 and 28% had GS>7. Doubtful PET/CTs were in only 5.5% of pts. FCH detection rate was 45%, 24% and 11% at PSA <1 in pts with GS>7, GS=7 and GS<7, respectively; it was 64%, 35% and 31% at 1>PSA<2 and GS>7, GS=7 and GS<7, respectively and it was 91%, 74% and 71% at PSA≥2 and GS>7, GS=7 and GS<7. At univariate and multivariate analysis both GS=7 and GS>7 resulted as independent predictive factors of a positive FCH PET/CT (ORs: 0.19 and 0.31; p<0.001). Conclusions Higher GS has shown to be a strong predictive factor for a positive FCH PET/CT finding of recurrent PCa also at low biochemical failure (PSA ≤1ng/ml).