RT Journal Article
SR Electronic
T1 Whole-body PET/CT evaluation of tumor perfusion using generator-based <sup>62</sup>Cu-ETS: Validation by direct comparison to <sup>15</sup>O-water
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 446
OP 446
VO 55
IS supplement 1
A1 Fletcher, James
A1 Eitel, Jacob
A1 Logan, Theodore
A1 Mathias, Carla
A1 Ng, Yen
A1 Lacy, Jeffrey
A1 Hutchins, Gary
A1 Green, Mark
YR 2014
UL http://jnm.snmjournals.org/content/55/supplement_1/446.abstract
AB 446 Objectives The purpose of the present study was: (i) to demonstrate the feasibility of whole-body 62Cu-ETS PET/CT tumor perfusion imaging in patients with metastatic renal carcinoma; and (ii) to validate 62Cu-ETS as a quantitative marker of tumor perfusion by direct comparison to 15O-water perfusion imaging. Methods PET/CT imaging (64-slice Siemens Biograph) of 14 subjects with stage IV renal cell cancer was performed after i.v. administration of 15O-water (10-minute dynamic list mode study), followed 10-minutes later by i.v. 62Cu-ETS with the heart and at least one tumor in the PET field-of-view (6-min list mode study). Whole body imaging of the 62Cu was then carried out from 6-20 min using 2-3 minutes/bed. Proportional Technologies, Inc. produced and shipped the required 62Zn/62Cu-generators, and the lyophilized cold kits for on-demand preparation of the 62Cu-ETS radiopharmaceutical (IND #75,018). Blood flow (k1) was quantified with both agents for both normal and malignant tissues in the 21.7 cm dynamic field-of-view. The required arterial input functions were derived from the left atrium, and in the case of 62Cu-ETS, corrected for partial decomposition of the agent by blood using data from an in vitro analysis with a sample of each patient’s blood. Results A good correlation was found between the k1 values of the two agents. For the normal tissues (muscle, myocardium, and thyroid), y = 0.909x + 0.106, r2 = 0.86, while the normal tissues plus malignant lesions in the bone and lung gave y = 0.824x + 0.160, r2 = 0.78. Paired 2-tailed t-test for normal and malignant tissues indicated no significant difference in k1 values between the two tracers. Conclusions 62Cu-ETS provided high quality whole-body PET/CT images, and appears suitable for use as a PET tracer of tumor perfusion in patients with metastatic renal carcinoma. Research Support RO1 CA 140299