PT  - JOURNAL ARTICLE
AU  - Salavati, Ali
AU  - Houshmand, Sina
AU  - Werner, Thomas
AU  - Alavi, Abass
TI  - Potential applications of molecular imaging in the diagnosis of deep vein thrombosis and pulmonary embolism
DP  - 2014 May 01
TA  - Journal of Nuclear Medicine
PG  - 1305--1305
VI  - 55
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/55/supplement_1/1305.short
4100  - http://jnm.snmjournals.org/content/55/supplement_1/1305.full
SO  - J Nucl Med2014 May 01; 55
AB  - 1305 Learning Objectives 1. To review different modalities for diagnosis and assessment of venous thromboembolism (VTE). 2. To discuss potential ability of molecular imaging as a preferred diagnostic tool in VTE. Venous thromboembolism (VTE) is often presented as lower extremity deep venous thrombosis (DVT) and pulmonary embolism (PE), which are both common and serious conditions. Highly effective, but potentially harmful therapy is available for acute VTE. However, the diagnosis cannot be established clinically due to unspecific symptoms and signs, and therefore diagnostic imaging is of vital importance. Duplex ultrasonography has become more applicable compared to contrast venography for the diagnosis of acute deep vein thrombosis (DVT). FDG-PET can be used to image the vasculature inflammation, which contributes to VTE. In this exhibits we will briefly review the following topics: 1. Current methods for diagnosis of DVT i. Contrast Venography ii. Duplex US (compression ultrasonography; CUS) iii. CT Venography iv. SPECT a. 99mTc labelled Anti D-Dimer b. 99mTc-apcitidine scintigraphy: IIb/IIIa receptor-binding polypeptide c. 111In labeled antifibrin antibody d. 99mTc-Plasmin v. FDG-PET/CT vi. Near Infrared fluorescence imaging 2. Current methods for diagnosis of pulmonary embolism i. Angiography ii. Ventilation-perfusion scintigraphy iii. CT angiography iv. MR angiography v. SPECT/CT a. 99mTc labelled Anti D-Dimer