PT  - JOURNAL ARTICLE
AU  - Kwon, Jeongil
AU  - Lee, Chang-Moon
AU  - Lee, Tai Kyoung
AU  - Hwang, Hyosook
AU  - Na, Kyung Suk
AU  - Jeong, Hwan-Seok
AU  - Kim, Eun-Mi
AU  - Lim, Seok Tae
AU  - Sohn, Myung-Hee
AU  - Hwan-Jeong, Jeong
TI  - The effect of I-131 labeled chitosan micro-hydrogels for transarterial radioembolization in a rodent hepatoma model
DP  - 2014 May 01
TA  - Journal of Nuclear Medicine
PG  - 1182--1182
VI  - 55
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/55/supplement_1/1182.short
4100  - http://jnm.snmjournals.org/content/55/supplement_1/1182.full
SO  - J Nucl Med2014 May 01; 55
AB  - 1182 Objectives Transarterial embolization has been used as one of therapeutic modalties against liver cancers. It keeps blood supply of tumor interrupted by embolic particles infused into hepatic arteries via a catheter. In this study, we prepared chitosan-based micro-hydrogels for hepatic arterial radio-embolization to treat a hepatoma. Methods Chitosan was conjugated with sulfo-succinimidyl-3-(4-hydroxypheynyl) propionate (SHPP) as a chelator for I-131 labeling and then the chitosan-SHPP conjugate was formulated into a spherical micro-hydrogels using an electro-spinning method. The micro-hydrogels were separated by centrifugation and suspended in phosphate buffer. To evaluate therapeutic effects the micro-hydrogels were infused in a rat of the hepatic artery using a catheter. Finally, gamma images were acquired to identify the retention of the micro-hydrogels in the infused hepatic lobes and the other organs. Results I-131 labeling efficiency of chitosan-SHPP was 60±5% and the radiolabeling stability was more than 90% for one week. The size of chitosan micro-hydrogels was 150±10 µm. The infused I-131 labeled chitosan micro-hydrogels were almost localized to the left hepatic lobe having an orthotopic hepatoma. In particular, there were no any significant leakage of I-131 to the other organs, especially to lungs and thyroid glands. Conclusions The characteristics of chitosan micro-hydrogels, such as I-131 labeling efficiency, radiolabeling stability, particle size, and retention in a hepatic tissue, indicate that the micro-hydrogels are compatible to effective transarterial radioembolization (TARE) for hepatoma therapy. I-131 labeled chitosan micro-hydrogels infused through the hepatic artery significantly decreased the tumor volume in a rat hepatoma model. As the results, I-131 labeled chitosan micro-hydrogels show the good possibility as a new material for effective hepatoma therapy.