PT  - JOURNAL ARTICLE
AU  - Wu, Ping
AU  - Ma, Yilong
AU  - Zuo, Chuantao
AU  - Peng, Shichun
AU  - Yu, Huan
TI  - Abnormalities in PDRP expression and striatal DAT binding in patients with idiopathic rapid-eye-movement sleep behavior disorder
DP  - 2013 May 01
TA  - Journal of Nuclear Medicine
PG  - 159--159
VI  - 54
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/54/supplement_2/159.short
4100  - http://jnm.snmjournals.org/content/54/supplement_2/159.full
SO  - J Nucl Med2013 May 01; 54
AB  - 159 Objectives Patients with idiopathic rapid-eye-movement sleep behaviour disorder (RBD) may develop Parkinson's disease (PD). In PD patients, reduced dopamine transporter (DAT) binding and elevated expression of PD-related spatial covariance pattern (PDRP) can be detected with PET imaging. In this study, we investigated the abnormalities in PDRP activity and striatal DAT distribution in RBD patients by using 18F-FDG PET and 11C-CFT PET respectively. Methods Resting-state brain 18F-FDG PET imaging was performed on a Siemens Biograph 64 PET/CT in a cohort of 12 RBD patients (age: 63.3±5.3 yr, mean±sd) and 12 age-matched healthy controls (age: 63.4±5.9 yr). PDRP expression was computed in each subject based on the PDRP we previously identified in a cohort of 33 PD patients and 33 healthy controls. The same RBD patients and another 12 age-matched healthy controls (age: 61.1±9.8 yr) underwent 11C-CFT PET imaging. The striatum to occipital cortex binding ratios were calculated for each striatal region. Differences in PDRP expression and 11C-CFT binding between patients and controls were assessed by use of independent-sample t-tests. All analyses were performed using SPSS software and considered significant for P < 0.05. Results Computed PDRP scores in the RBD patients were abnormally elevated (P< 0.001) relative to those in the normal subjects. Mean 11C-CFT binding in the RBD patients reduced significantly in all striatal regions compared with the controls (caudate nucleus: P=0.010; anterior putamen: P=0.004; posterior putamen: P=0.003). Conclusions Increased PDRP expression and decreased striatal 11C-CFT binding can be detected in patients with iRBD. These measures from dual-tracer studies might provide useful imaging biomarkers to identify individuals at increased risk for development of PD. Research Support the National Foundation of Natural Science of China (No. 81171189)