RT Journal Article
SR Electronic
T1 Age decline in the subcortical 5-HT6 receptor as imaged in male volunteers
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 28
OP 28
VO 54
IS supplement 2
A1 Matuskey, David
A1 Park, Eunkyung
A1 Nabulsi, Nabeel
A1 Planeta, Beata
A1 Esterlis, Irina
A1 Williams, Wendol
A1 D'Souza, Deepak Cyril
A1 Huang, Yiyun
A1 Morris, Evan
A1 Carson, Richard
YR 2013
UL http://jnm.snmjournals.org/content/54/supplement_2/28.abstract
AB 28 Objectives Previous imaging studies have suggested an age-related decline in brain serotonin (5-hydroxytryptamine or 5-HT) measures in healthy subjects. This project seeks to investigate via positron emission tomography (PET) imaging whether the availability of 5-HT6 is also changed with age. Methods Twenty-nine healthy control subjects (all males; mean age 36±9; range 23-52 years) were scanned with the PET radiotracer [11C]GSK215083 that exhibits high binding affinity for the 5-HT6 receptor specifically localized in the striatum. Dynamic PET scans were acquired on the Siemens HR+. An early summed PET image was created and registered to the subject’s 3T MR anatomical image (6-parameter affine registration) which was then registered to an MR template using a non-linear transform with Bioimagesuite. Automatic regions-of-interest (Anatomical Automatic Labeling (AAL) for SPM2) were then applied to generate time-activity curves (TACs) in the striatum (caudate and putamen). The 90-min TACs were fitted with the MA1 (t*=40) model with a metabolite-corrected arterial input function, and regional binding potential (BPND) was calculated from the fitted VT values using the cerebellum as the reference region. Results Regional [11C]GSK215083 BPND displayed a negative correlation with age in the caudate (r = -0.51, P = 0.005) and putamen (r = -0.46, P = 0.01). 5-HT6 receptor availability in these two brain regions were found to be 22% (caudate) and 13% (putamen) lower with each decade of life studied. Conclusions PET imaging studies with [11C]GSK215083 infer an age-related decrease in 5-HT6 receptors in the striatum of healthy males. These findings indicate that age is a relevant factor to take into account when studying potential 5-HT6 receptor alterations in psychiatric disorders.