PT  - JOURNAL ARTICLE
AU  - David M. Wilson
AU  - John Kurhanewicz
TI  - Hyperpolarized <sup>13</sup>C MR for Molecular Imaging of Prostate Cancer
AID  - 10.2967/jnumed.114.141705
DP  - 2014 Oct 01
TA  - Journal of Nuclear Medicine
PG  - 1567--1572
VI  - 55
IP  - 10
4099  - http://jnm.snmjournals.org/content/55/10/1567.short
4100  - http://jnm.snmjournals.org/content/55/10/1567.full
SO  - J Nucl Med2014 Oct 01; 55
AB  - Hyperpolarization using dissolution dynamic nuclear polarization has emerged as a versatile method to dramatically improve the MR signal of low-sensitivity nuclei. This technique facilitates the study of real-time metabolism in vitro and in vivo using 13C-enriched substrates and has been applied to numerous models of human disease. In particular, several mechanisms underlying prostate cancer have been interrogated using hyperpolarized 13C MR spectroscopy. This review highlights key metabolic shifts seen in prostate cancer, their study by hyperpolarized 13C MR spectroscopy, and the development of new platforms for metabolic study.