PT - JOURNAL ARTICLE AU - Yu, A Ram AU - Kim, Jin Su AU - Woo, Sang-Keun AU - Kim, Kyeong Min AU - Kim, Hee Joung AU - Lim, Sang Moo TI - Development of voxel-based statistical analysis method for quantitative analysis of heart PET image DP - 2012 May 01 TA - Journal of Nuclear Medicine PG - 2329--2329 VI - 53 IP - supplement 1 4099 - http://jnm.snmjournals.org/content/53/supplement_1/2329.short 4100 - http://jnm.snmjournals.org/content/53/supplement_1/2329.full SO - J Nucl Med2012 May 01; 53 AB - 2329 Objectives Voxel based statistical analysis for brain image was widely used. Although, polar map is widely used for the analysis in heart PET; however, there was a limitation of analysis in image space. In this study, we newly developed the voxel based statistical analysis method for myocardial PET. Methods A Siemens Inveon PET was used. Myocardial infarct (MI) model was constructed. FDG PET for MI model and normal rats (N=12, weight; 250~270 g) were acquired for 1 hr after injection of 0.8 mCi FDG. List-mode data were sorted into sinograms and then reconstructed using 3DRP methods (matrix size = 256 × 256 × 159, voxel sizes = 0.017 × 0.017 × 0.079 cm3). For the SPM analysis, myocardial PET data was extracted using imaging masking. After selecting target image for spatial normalization, individual PET data was spatially normalized and averaged. Individual PET data was spatially normalized onto the template. To increase the signal-to-noise ratio, a 2 mm Gaussian kernel was used for smoothing. Two sample t-tests were performed to identify the myocardial infarct region. This developed SPM method was compared with conventional ROI methods. Results Myocardial glucose metabolism was decreased in the region of lateral wall of left ventricle (p < 0.05, k > 0). In the result of ROI analysis, the mean value of lateral wall was 29% decreased. Conclusions We developed the voxel-based analysis of rat heart PET data and identified the myocardial infarct region. Newly developed SPM method for myocardial PET could provide an quantitative information in myocardial PET study