RT Journal Article
SR Electronic
T1 Helical tomotherapy treatment planning of lymph-node relapses in prostate cancer: Clinical value of 11C-Choline PET/CT
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1155
OP 1155
VO 53
IS supplement 1
A1 Busnardo, Elena
A1 Picchio, Maria
A1 Berardi, Genoveffa
A1 Crivellaro, Cinzia
A1 Mapelli, Paola
A1 Pappalardi, Brigida
A1 Giovacchini, Giampiero
A1 Gianolli, Luigi
A1 Di Muzio, Nadia
A1 Messa, Cristina
YR 2012
UL http://jnm.snmjournals.org/content/53/supplement_1/1155.abstract
AB 1155 Objectives To evaluate the role of 11C-Choline PET/CT as image-guide tool for tomotherapy treatment(HTT)of lymph-node relapses and for treatment monitoring in prostate cancer patients. Methods 31 prostate cancer pts with biochemical recurrence after primary treatment (mean PSA0:14,12 ng/ml) performed PET/CT0 for restaging and planning treatment.PET/TC0 positive pelvic and abdominal lymph nodes were treated with high dose using simultaneous boost (n=34 treatments).After the end of HTT PSA1 was measured and compared to PSA0 to evaluate biochemical response;in 24/34 pts a PET/CT1 scan was repeated to assess metabolic response.In 25/34 treatments, a further PSA2 measurement was recorded; in 13/25 cases a PET/CT2 was performed.PSA2 and PET/CT2 were compared to the basal ones. Results PET/CT0 showed 34 sites of nodal involvement (20 pelvic,8 abdominal,6 pelvic+abdominal) that were included in treatment planning.PSA1 (mean 4.55 ng/ml; range 0.00-46.39 ng/ml) showed biochemical response after HTT in 31/34 cases and progression in 3/34 while PSA2 (mean 0.98ng/ml; range 0.00-10.71 ng/ml) in 19/25 and 6/25 treatments respectively. Metabolic response at treated areas at PET/CT1 resulted:complete (CMR) in 11/24, partial (PMR) in 9/24, progression disease (PD) in 2/24 and stable disease (SD) in 2/24. In 4/24 cases distant metastases were detected. PET/CT2 showed CMR in 11/13, PMR in 1/13 and PD in 1/13 on treated areas. Distant metastases occurred in 4/13 cases. Conclusions 11C-Choline PET/CT is a valuable tool for planning and monitoring HTT treatment on lymph nodal relapse. HTT and concomitant systemic therapy are effective as demonstrated by the good rate of local control