RT Journal Article
SR Electronic
T1 The kinetics and reproducibility of 18F-Sodium Fluoride (NaF) PET imaging
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1250
OP 1250
VO 53
IS supplement 1
A1 Kurdziel, Karen
A1 Shih, Joanna
A1 Apolo, Andrea
A1 Lindenberg, Liza
A1 Mena, Esther
A1 McKinney, Yolanda
A1 Turkbey, Baris
A1 Dahut, William
A1 Landgren, Ola
A1 Choyke, Peter
YR 2012
UL http://jnm.snmjournals.org/content/53/supplement_1/1250.abstract
AB 1250 Objectives Although Sodium Fluoride (18F-NaF) bone scanning has been used for many decades, recent advances in PET-CT camera technology mandate a reappraisal of recommended doses and scanning guidelines. We evaluated the kinetics of 18F-NaF using a current PET-CT scanner to reassess the recommended dose, optimal uptake period and inter-study reproducibility. Methods In this prospective study, 73 patients underwent multiple sequential PET/CT images after receiving 3-5mCi 18F-NaF IV. Twenty-one of these patients underwent repeat baseline studies (mean interval 5 days) to evaluate reproducibility. Results Imaging with doses in the range of 3-5mCi 18F-NaF produces excellent scan quality. Estimated Radiation dosimetry made using OLINDA1.0, yield an estimated Effective Dose (ED) of 0.062rem/mCi with the urinary bladder, osteogenic cells and the red marrow receiving the highest doses at 0.300, 0.288 and 0.104 rad/mCi respectively. Visual analysis shows that uptake in both normal and abnormal bone increase with time, however, the rate of increase decreases with time. A semi-automated workflow was created (MIM5.2) to provide objective uptake parameters, including the SUV10mean (mean SUV of all pixels within bone with SUV >10) and the mSUVmean (the average of the SUVmean of all malignant lesions identified by the algorithm). The rate of change between 60 and 120minutes for SUV10mean and mSUVmean is 0.1 %/minute. At 60minutes p.i. critical percent differences of 20.9% for SUV10mean and 33.2% for mSUVmean were achieved. This indicates that SUV changes must be greater than these critical values if they are to be considered “real” during treatment monitoring. Conclusions 18F-NaF PET/CT images can be obtained with modest radiation exposures and can result in highly reproducible imaging parameters at a 60 minute uptake period. This may enable more quantitative measurement of metastatic bone disease. Research Support Center for Cancer Research/ NCI Intramural Progra