RT Journal Article
SR Electronic
T1 Clinical investigation of dynamic PET/CT imaging using O-([18F]fluoromethyl)-D-tyrosine (D-18F-FMT, BAY 86-9596) in oncological patients
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1676
OP 1676
VO 53
IS supplement 1
A1 Burger, Irene
A1 vonSchulthess, Gustav
A1 Zitzmann-Kolbe, Sabine
A1 Kowal, Kristin
A1 Bacher-Stier, Claudia
A1 Loeffler, Dirk
A1 Tutic, Michaela
A1 Haerle, Stephan
A1 Pruim, Jan
A1 Hany, Thomas
YR 2012
UL http://jnm.snmjournals.org/content/53/supplement_1/1676.abstract
AB 1676 Objectives The aim of this study was the analysis of tracer dynamics of O-([18F]fluoromethyl)-D-tyrosine (D-[18F]-FMT, BAY 86-9596), a novel labelled tyrosine derivative, in oncological patients and to determine optimal image acquisition time represented by the highest tumor to blood pool ratio (T/BP). Methods Six patients with biopsy proven non small cell lung cancers or head and neck squamous cell carcinomas were prospectively included in this IRB approved study. In all 6 patients 3 whole body (WB) scans were acquired after the injection of 300 MBq D-18F-FMT (30, 45 and 60 minutes). Three patients underwent additional dynamic imaging after injection over the tumor region. The dynamic data of the first 3 patients were extrapolated to 60 minutes using the additional three data points from the available WB scans to determine Blood pool activity (BP) and T/BP. Results Blood pool activity showed a fast initial peak of D-[18F]-FMT in the first three minutes, representing tracer distribution in the body, followed by slower blood pool clearance. D-[18F]-FMT kinetic in tumor showed an increase over the first 15 minutes after injection with a plateau phase until 25 minutes after injection followed by a slow decrease. D-[18F]-FMT T/BP for the 3 patients between 20 and 60 minutes was 1.6 ± 0.2, 3.5 ± 1.2 and 1.8 ± 0.3, respectively. No increase in T/BP was seen in the later WB scans. Subjective visually optimal contrast by better tumor delineation was seen in 4 patients after 30 minutes and in 2 patients after 45 minutes. Conclusions D-[18F]-FMT is rapidly accumulating over the first 25 minutes in tumor tissue and shows a washout that parallels blood pool. Optimal imaging time point seems to be around 30-45 minutes after injection. Research Support Study was financially supported by Bayer AG