RT Journal Article SR Electronic T1 Relationship between the cardiac lesion and the other organ involvements of sarcoidosis using 18F-FDG PET JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1794 OP 1794 VO 53 IS supplement 1 A1 Manabe, Osamu A1 Yoshinaga, Keiichiro A1 Ohira, Hiroshi A1 Klaipetch, Alisa A1 Oyama-Manabe, Noriko A1 Tsujino, Ichizo A1 Sato, Takahiro A1 Magota, Keiichi A1 Nishimura, Masaharu A1 Tamaki, Nagara YR 2012 UL http://jnm.snmjournals.org/content/53/supplement_1/1794.abstract AB 1794 Objectives Sarcoidosis is a non-caseating granulomatous disease with multiorgan involvements. Recently the diagnosis using 18F-FDG PET is proposed with its higher sensitivity. Our aim of this study was to evaluate the relationship between the cardiac lesion and the other organ involvements using 18F-FDG PET. Methods Fifty sarcoidosis patients, who were histologically proven, with abnormal ECG or echocardiography findings were included (11 male, 39 female, 56.3±14.9 years old). All patients continued the fasting at least 6 hours and unfractionated heparin (50 IU/kg) was injected intravenously 15 minutes prior to reduce the physiological uptake. We decided that uptake was positive if there was obvious accumulation on myocardium or the other organs. Results 32 patients showed the abnormal focal myocardial uptake. For the analysis of the lymph node, 44 patients showed the abnormal uptake. The patients with supraclavicular or abdominal lymph node uptake were significant interaction with the cardiac involvements (p=0.018, 0.006). In contrast, there was no significant relation between the cardiac involvements and hilar, mediastinum lymph node uptake (p=0.21, 0.42). For the analysis of the other organ, 18 patients were suspected to have the involvements. The uptake of the skin lesions were not significantly correlated to the cardiac abnormal uptakes (p=0.68), on the other hand, combined with the other involved organs such as lung, liver, spleen, bone, muscle were tended to be correlated to the cardiac disease (p=0.056). Conclusions The sarcoidosis patients with other organ and/or remote nodal lesion might increase the likelihood of having cardiac sarcoidosis. Therefore, it might be important to evaluate the cardiac involvement, if there is other organ and/or remote nodal involvement