RT Journal Article
SR Electronic
T1 Comparing FDG quantification in tumors with the retention fraction and SUV in a dual scan examination after 60 and 90 minutes
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 2095
OP 2095
VO 52
IS supplement 1
A1 Irene Burger
A1 Dominic Huser
A1 Gustav vonSchulthess
A1 Niklaus Schaefer
A1 Josephine Trinckauf
A1 Cyrill Burger
A1 Alfred Buck
YR 2011
UL http://jnm.snmjournals.org/content/52/supplement_1/2095.abstract
AB 2095 Objectives To determine and compare the time variability of the standard uptake value (SUV) and the retention fraction (RF) for FDG quantification between 60 and 90 minutes. Methods We analyzed 16 patients referred for staging or follow up of malignant disease. 60 minutes after injection of 350 MBq FDG using an automatic injector, partial body PET/CT images were acquired. Thirty minutes after imaging the PET acquisition of the tumor was repeated. The tumor RF was calculated for both scans by dividing the tumor uptake (kBq/cc) by the integral of a population based input curve. This input curve was calibrated with the measured blood pool activity in the aortic arch in scan 1. SUVmax and RFmax were determined in the same volume of interest (VOI) in both scans. Results The relative changes for SUVmax between scan two and one was 13.4±7.8% (-2.1 - 34.7%). In comparison the relative change for RFmax was significantly smaller with 0.5±6.5% (-13.5 - 17.4%) (p<0.001). Conclusions FDG quantification using RF is significantly less time dependent between 60 and 90 minute, than SUV. Therefore RF may be a better quantifier for FDG uptake/metabolism more compatible with clinical reality where start times for the PET scan cannot always be tightly controlled. Research Support Non