TY - JOUR T1 - Assessment of image quality using mouse, rat, and mid-sized animal brain phantoms JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 2068 LP - 2068 VL - 52 IS - supplement 1 AU - A Ram Yu AU - Jin Su Kim AU - Kyeong Min Kim AU - JongGuk Kim AU - Ji-Ae Park AU - Sang-Keun Woo AU - Hee Joung Kim AU - Sang Moo Lim Y1 - 2011/05/01 UR - http://jnm.snmjournals.org/content/52/supplement_1/2068.abstract N2 - 2068 Objectives To assess image quality (IQ) of animal PET images, the NEMA NU-4 2008 IQ phantom was used. This IQ phantom was similar than a typical mouse. However, rat brain/whole body PET and mid-sized animal brain PET are also widely performed. To assess the IQ of rat and mid-sized animal brain PET images, phantoms were created, and parameters of IQ such as uniformity and spillover ratio (SOR) were assessed. To compare the IQ, PET data of the IQ phantom were also acquired. Methods Siemens Inveon PET scanner was used throughout. Rat (L: 150 mm, Φ: 50 mm) and mid-sized animal brain (L: 130 mm, Φ: 80 mm) phantoms were created. 18F was injected at a dose of 100 μCi, 1.4 mCi, and 2.4 mCi for the assessment of IQ, rat, and mid-sized animal brain phantoms, respectively. The energy window was set at 350~650 keV; the time window, at 3.432 nsec. Next, 3D list-mode PET data were acquired for 20 min; the data were sorted into a sinogram using FORE and reconstructed using 2D FBP with a ramp filter. Attenuation and scatter corrections were performed. To measure uniformity, a volume of interest (VOI) was drawn at the center of the uniform region. Uniformity was expressed as percent standard deviation (%SD). Two cylindrical VOIs in the air- and water-filled compartments were drawn. The SOR was defined as the ratio of the mean value in each cold cylinder to the mean value in the uniform area. Results The uniformities were 7.2%, 14.3% and 29.0% for the IQ, rat, and mid-sized animal brain phantoms, respectively. The SOR values in the air-filled compartments were 1.9%, -0.5%, and -5.2%, respectively. The SOR values in the water-filled compartments were -0.6%, 3.7%, and 6.0%, respectively. Conclusions These results showed the IQ of mouse, rat, and mid-sized animal brain PET images. This information would be helpful in quantifying PET data ER -