RT Journal Article
SR Electronic
T1 Validation of neuroreceptor PET based subdivision of human cingulate cortex parcellated on MRI
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1198
OP 1198
VO 52
IS supplement 1
A1 Jongho Kim
A1 Hiroto Kuwabara
A1 James Brasic
A1 Elise Weerts
A1 Mary McCaul
A1 Gary Wand
A1 Dean Wong
YR 2011
UL http://jnm.snmjournals.org/content/52/supplement_1/1198.abstract
AB 1198 Objectives To examine whether parcellation of Brodmann areas 25 (ventral subgenual anterior CC, vACC25) and 31 (dorsal posterior CC, dPCC31), in addition to cingulate proper (CC) and paracingulate (PaC) cortex (a Fornito model, 2006) improves measurements of PET binding potential (BP) over our recent PET-based model (Neuroimage 52:S194, 2010). Methods Three groups of healthy subjects enter the study who had [11C]DASB (n=10), [11C]MDL100,907 (n=10), and [11C]carfentanil (n=10), serotonin transporter (SERT), and 5HT2A and µ-opioid receptor ligands, respectively. On MRI, CC, PaC, vACC25 and dPCC31 were semi-automatically parcellated according to Fornito model (4 subdivisions). Then, combined CC VOIs were divided into anterior (aC), middle (mC), and posterior (pC) using commissural planes (Vogt 2003), while aC was further divided into ventral (vaC), rostral (raC), and dorsal (daC) using anterior tip of corpus callosum (Bush 2000) to complete 5 subdivision model. Regional BP were obtained for VOIs of Fornito and 5 subdivision models using multi-linear reference tissue method with 2 parameters (MRTM2; Ichise, 2002). Regional BP were compared using paired t-test with Bonferroni correction. Results Structural vACC25 showed the highest SERT (p<0.01) and µ-opioid BP (p<0.05), and the lowest 5HT2A BP (p<0.01) among Fornito model VOIs, and significantly different from corresponding values of vaC (p<0.05, respectively) of 5 subdivision model that includes vACC25. dPCC31 showed significantly lower SERT (p<0.01) and higher 5HT2A BP (p<0.05) than those on pC which includes dPCC31. Conclusions vACC25 and dPCC31 showed distinctive BP within conventional, PET-based subdivisions of aC and pC, respectively for SERT, 5HT2A and µ-opioid receptors, necessitating separate VOIs. Development of CC subdivision method might be needed and specific to individual receptor/transporter systems. Research Support NIBIB, NIDA, NIAAA (5T32EB006351-05) (JK