TY - JOUR T1 - Head motion evaluation and correction for PET scans with 18F-FDG in the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI) multi-center study JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 2091 LP - 2091 VL - 52 IS - supplement 1 AU - Yasuhiko Ikari AU - Tomoyuki Nishio AU - Yoko Makishi AU - Yukari Miya AU - Michio Senda AU - Kengo Ito AU - Robert Koeppe Y1 - 2011/05/01 UR - http://jnm.snmjournals.org/content/52/supplement_1/2091.abstract N2 - 2091 Objectives Head motion during PET scans degrades the image quality, which is an issue in a multi-center study on dementia involving inexperienced sites. This study evaluated the degree of head motion and its correction technique by J-ADNI PET QC core. Methods Brain FDG-PET scans of 172 subjects (Normal:81, MCI:55, mild-AD:36) were acquired as multi-frames data (5min*6) at 23 PET centers with 13 different camera models. Data were corrected for motions using the coregistration software by NEUROSTAT and were classified into 6 levels of motion degree ([A]:No-Motion /[B]:Mild /[C]:Mild-to-Moderate/ [D]:Moderate /[E]:Moderate-to-Severe/ [F]:Severe) according to the magnitude of the coregistration affine parameters. Bad frames were omitted because of incorrect attenuation correction. ROI analysis was performed on the images with and without motion correction. Results The 172 scans were classified into 38 [A], 76 [B], 32 [C], 13 [D], 7 [E] and 6 [F] level. Mild-AD group tended to present larger motion than MCI and Normal groups, although large motion (level [E], [F]) was also observed in a fraction of the latter. Inter-frame ROI variations for uncorrected level [F] subject was substantially larger than but was corrected to the range similar to level [A] subject. The absolute % difference in the frontal cortex ROI values between motion-corrected and uncorrected frame-averaged images for 6 subjects in each level was 0.24±0.04 % for [A], 0.37±0.12 % for [B], 0.44±0.16 % for [C], 0.46±0.25% for [D], 0.82±0.58 % for [E] and 1.39±1.07 % for [F] (mean±SD). Conclusions The head motions during PET scans significantly affects the quantitative results, which frequently occurs in demented patients but is inevitable for normal subjects, and the correction technique in J-ADNI reduces the image degradation. Research Support J-ADNI Projec ER -