TY - JOUR T1 - Equalizing reality: Producing comparable imaging results with Siemens Inveon DPET and GE XPET JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 2094 LP - 2094 VL - 52 IS - supplement 1 AU - Christian Wietholt AU - Ing-Tsung Hsiao AU - Chad Haney AU - Chin-Tu Chen Y1 - 2011/05/01 UR - http://jnm.snmjournals.org/content/52/supplement_1/2094.abstract N2 - 2094 Objectives Since the commercialization of dedicated preclinical imaging equipment, many manufacturers have distributed instruments with different designs and made for various imaging tasks. Our current study, examines difference in system performance of a Siemens Inveon DPET and a GE XPET, and their affects on image quality and quantification. This effort is motivated by the desire to conduct identical in-vivo experiments on different imaging equipment and integrating the results into one analysis. Methods For this purpose, system parameters such as uniformity, spatial resolution, sensitivity, count rate and scatter fraction were determined for each instrument. The measured parameters were evaluated and correlated to the results from images that were acquired using an image quality phantom. System performance and quality measurements were conducted following the NEMA NU-4 standard. PET data was reconstructed using the vendor recommended reconstruction protocols. Results Among other results, our initial experiments show a spatial resolution ranging from 2.20 - 4.94 mm for the XPET and 1.32 - 12.92 mm for the DPET depending on the location of the point source and along which axis the resolution was measured. Uniformity measurements showed a percentage standard deviation of 5.51 %STD and 10.21 %STD for the XPET and DPET, respectively. The spill over ratio for cold water and air was 0.1 and 0.2 for the XPET, respectively, and 0.3 for the DPET. Conclusions The system resolution directly effects the recovery coefficients of the rod sources in the image quality phantom, where the 1mm rod is not visible in the XPET images, but can be noticed in the DPET images. To make a more conclusive statement, further parameters need to be measured and analyzed. Research Support This work was supported in part by NIH grant S10RR022520 ER -