RT Journal Article
SR Electronic
T1 SUVmax is not related to tumor grade in epithelial ovarian cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1848
OP 1848
VO 52
IS supplement 1
A1 Karantanis, Dimitrios
A1 Allen-Auerbach, Martin
A1 Czernin, Johannes
YR 2011
UL http://jnm.snmjournals.org/content/52/supplement_1/1848.abstract
AB 1848 Objectives To determine the potential relationship between the 18F FDG glycolytic phenotype and the tumor grade or histologic subtype in epithelial ovarian cancer patients. Methods The charts of all patients referred for 18F FDG PET/CT scan with the indication “ovarian cancer” were surveyed. Included patients had pathologic confirmation of epithelial ovarian cancer, no other concurrent malignancies, had PET/CT either before or at least 3 months after any therapeutic intervention and had confirmed, measurable in size >1cm disease at the time the PET was done. The FDG uptake was determined as SUVmax at the pathologically confirmed site of disease or, otherwise in the most active lesion. SUVmax was correlated to the tumor grade and histology subtype using regression analysis. Results Overall, 171 ovarian cancer patients were referred for 18F FDG PET/CT. Forty-two were eligible for inclusion. Mean age (SD) was 61.4 (13.6) years. Thirty-two patients had serous, 1 had mucinous, 4 endometrioid, 2 clear cell, 1 transitional cell, and 2 had mixed histology. Five patients had grade I, 7 had grade II, and 28 patients had grade III epithelial ovarian cancer. In one patient the grade was not determined and in another one was intermediate. The tumor exhibited a strong glycolytic phenotype (average SUVmax 7.7, range 1.9-18.1, median 6.6). Average SUVmax was 7.8 for grade I, 6.8 for grade II, and 8.0 for grade III. There was no statistically significant correlation between the glycolytic phenotype as determined by SUVmax and the histology grade (p=0.736 ). No statistically significant correlation was also found for the uptake between the two different histologic subtypes of serous and endometriod ovarian cancer ( p=0.533 ). For mucinous, clear cell and transitional cell subtypes no statistic evaluation was possible due to the low number of cases. Interestingly, in 2 cases with the more aggressive clear cell subtype, the uptake was low ( SUVmax of 3.1 and 3.2). Conclusions Epithelial ovarian cancer demonstrates high 18F FDG uptake. However, the glycolytic phenotype expressed as SUVmax is unrelated to the tumor grade and histologic subtyp