RT Journal Article
SR Electronic
T1 FDG PET imaging of rhesus monkeys with symptoms characteristic of obsessive compulsive disorder (OCD) in humans
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1191
OP 1191
VO 52
IS supplement 1
A1 Ali Bonab
A1 Michael Campos
A1 Jennifer Camacho
A1 Donald McLaren
A1 Alan Fischman
A1 Elisabeth Ludlage Moeller
A1 Amanda Duffy
A1 Steven Niemi
A1 Emad Eskandar
A1 Darin Dougherty
YR 2011
UL http://jnm.snmjournals.org/content/52/supplement_1/1191.abstract
AB 1191 Objectives Human Obsessive Compulsive Disorder (OCD) has not been identified in non-human primates (NHP). Recently we have identified abnormal behaviors in monkeys that are similar to OCD in humans. In this report we used FDG brain PET imaging to assess these behavioral issues. Methods Methods: We imaged 4 normal monkeys and 4 monkeys with substantial expression of abnormal behavior based on continuous observation and assessment. After injection of ~4 mCi of 18FDG each monkeys was imaged for 60 minutes in list mode. Images were acquired with a Siemens P4 microPET. Data was Fourier rebind and reconstructed using map reconstruction in 256x256 matrices. Images were corrected for randoms, attenuation, scatter and dead time. P4 microPET has in-plane resolution of ~1.75 mm FWHM (Tai, et al Phys Med Biol 46:(2201) 1845-1862). Images were intensity normalized to the same global mean, spatially normalized to the 112RM-SL rhesus macaque atlas, and analyzed with statistical parametric mapping (SPM5). Results Preliminary results with this small sample indicate a significant activation in the anterior cingulate in monkeys exhibiting OCD-like behaviors compared with controls. This pattern corresponds to known activation patterns of human OCD patients. Conclusions These results suggest that NHPs that spontaneously exhibit OCD-like abnormal behaviors could be a useful model for human OCD, since they share a common endophenotype