TY - JOUR T1 - Fluorescence-guided occult lesion localization: Comparison with radio-guided occult lesion localization through a simple phantom study JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1969 LP - 1969 VL - 52 IS - supplement 1 AU - Lee Eun Seong AU - Se Hun Kang AU - Tae-Sung Kim AU - Seok-Ki Kim Y1 - 2011/05/01 UR - http://jnm.snmjournals.org/content/52/supplement_1/1969.abstract N2 - 1969 Objectives Recent diagnostic imaging technique has been improved to make it possible to visualize and detect tiny pathologic lesions. However, in current surgical practice, surgeons still depend on their own palpation and visual inspection, which leads to be difficult to find and remove tiny lesion precisely. Radioguided occult lesion localization (ROLL) has been introduced to overcome this problem but it is not always available. We developed fluorescence-guided occult lesion localization (FOLL) as an equivalent modality of ROLL. Methods Either radioactive or non-radioactive fluorescence containing E-P tubes were located behind the silicon breast phantom at different depth with 0.5, 1.5, and 2.0 cm, simulating radioactive or fluorescent indicators in pathologic lesions respectively. Total 6 tubes were located, half of them filled with 0.2 ml of Tc-99m pertechnate (12 MBq/ml) and the others with 0.2 ml of indocyanine green-human serum albumin (ICGHSA) (0.027mM as ICG). The phantom was scanned in a gamma camera, fluorescent camera, gamma probe and eventually our prototype fluorescence-sensing probe (FSP). Results All the radioactive tubes, located at the different depth level, were well detected by gamma camera and gamma probe. Only the most superficially located fluorescent tube (0.5mm) was detectable by fluorescent camera system. However, FSP recognized all the fluorescent tubes. FSP detected deepest-seated tube with stronger fluorescence signal when pressing the phantom over the fluorescent tube. FSP detected signals on the specific area above the tubes in spite of photon scattering and it could define the position more precisely than gamma probe. Conclusions FOLL using FSP showed better performance than using fluorescent camera and showed equivalent efficacy to ROLL in this limited situation, which suggests that the FOLL could be clinically applicable with no radiation exposure, convenience and more precise localization ER -