RT Journal Article
SR Electronic
T1 68Ga-DOTANOC PET/CT accuracy for neuroendocrine (NET) lesions detection: The Bologna experience
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1298
OP 1298
VO 52
IS supplement 1
A1 Ambrosini, Valentina
A1 Campana, Davide
A1 Nanni, Cristina
A1 Allegri, Vincenzo
A1 Castellucci, Paolo
A1 Nicolini, Silvia
A1 Fantini, Lorenzo
A1 Montini, Gian Carlo
A1 Tomassetti, Paola
A1 Fanti, Stefano
YR 2011
UL http://jnm.snmjournals.org/content/52/supplement_1/1298.abstract
AB 1298 Objectives To evaluate the accuracy of 68Ga-DOTANOC PET/CT in patients with known or suspected NET. Methods We included the patients with known or suspected NET referred to us by the Internal Medicine Unit. All patients (204) underwent 68Ga-DOTANOC PET/CT at our centre and completed an extensive clinical and imaging follow-up of at least 12 months. Indications to perform PET included staging (18), re-staging after surgery or therapy (39), interim PET (16), follow-up (78), equivocal CI (27) or markers (3), UPC (13), suspected NET in unexplained diarrhea (7) or suspected insulinoma (1) and screening in MEN (2). Clinical and imaging follow-up was used as standard of reference to finally describe PET results as true positive, true negative, false positive and false negative. Results We evaluated 204 patients with known (188) or suspected (16: 7 unexplained diarrhea, 7 suspected NET lesions on conventional imaging, 2 screening in MEN) NET lesions. In 126 cases the primary was excised before PET/CT. The most frequent primary site was the GI tract (137/204) followed by lungs (38), ear (6), ovary (1) and kidney (1). In 21 cases the primary was not identified: 5 unknown primary in patients with NET metastasis, 16 suspected NET lesions on CT (not confirmed on neither PET nor pathology). At the time of the PET scan, 89 patients were receiving therapy (SST, PRRT, chemotherapy, alone or in combination) while 115 were untreated. Overall and site by site PET sensitivity, specificity, positive (PPV) and negative (NPV) predictive values are reported in table 1. "" Conclusions 68Ga-DOTANOC PET/CT was accurate for the detection of NET lesions, particularly at bone, lung and lymphnodes level