RT Journal Article
SR Electronic
T1 Regional cerebral activity associated with self-perception of memory problems in brains of breast cancer patients soon after adjuvant chemotherapy
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1235
OP 1235
VO 52
IS supplement 1
A1 Cheri Geist
A1 Kelsey Pomykala
A1 Daniel Silverman
A1 Patricia Ganz
A1 Lorna Kwan
A1 Julienne Bower
A1 Michael Irwin
A1 Johannes Czernin
A1 Michael Phelps
A1 Steven Castellon
YR 2011
UL http://jnm.snmjournals.org/content/52/supplement_1/1235.abstract
AB 1235 Objectives To examine relationships between self-reported cognitive complaints and regional cerebral activity in patients recently exposed to adjuvant chemotherapy. Methods Subjects (n=30) recently diagnosed with breast cancer and not yet on endocrine therapy were prospectively recruited; 21 had completed adjuvant chemotherapy while 9 had none. Subjects assessed their memory problems and other cognitive difficulties, and underwent resting brain FDG-PET scans, which were analyzed by standard volume of interest (sVOI) and statistical parametric mapping (spm) methods. Results Among the self-report subscales, perceived problems with memory differed the most between treatment groups, being significantly higher in subjects exposed to chemotherapy (ave±SEM, 2.05±0.06 vs. 0.03±0.2, respectively, on a 10-point scale; p=0.01). Memory complaints were negatively correlated with metabolism in brainstem (midbrain) by sVOI analysis (r=-0.6, p=0.007), and in bilateral inferior temporal cortex (sVOI p=0.004, spm p<0.0005), and positively correlated with metabolism of bilateral superior temporal and anterior cingulate cortex by both sVOI and spm analyses (cluster-corrected p≤0.04 with peak-voxel p<0.0005 for both areas). These correlations were not present in the untreated group. Conclusions Self-reported memory complaints in recently treated breast cancer patients positively correlated with metabolism in superior temporal and anterior cingulate cortex, and negatively correlated with metabolism of inferior temporal cortex and midbrain, demonstrating objective support for specific neurological substrates of what are often regarded as “subjective” perceptions. Research Support NCI R01-CA109650 & Breast Cancer Research Foundatio