PT - JOURNAL ARTICLE AU - Hiroshi Watabe AU - Keisuke Kiso AU - Eku Shimosegawa AU - Yasukazu Kanai AU - Kouichi Fujino AU - Jun Hatazawa TI - Quantitative myocardial blood flow imaging with [N-13]ammonia PET and basis function method DP - 2011 May 01 TA - Journal of Nuclear Medicine PG - 2055--2055 VI - 52 IP - supplement 1 4099 - http://jnm.snmjournals.org/content/52/supplement_1/2055.short 4100 - http://jnm.snmjournals.org/content/52/supplement_1/2055.full SO - J Nucl Med2011 May 01; 52 AB - 2055 Objectives Although [O-15]water is an ideal tracer for measurement of myocardial blood flow (MBF), [N-13]ammonia is well suited for quantification of MBF due to high extraction fraction and better image quality than [O-15]water. We developed a technique to compute parametric MBF image for [N-13]ammonia based on the basis function method (BFM). The BFM enables rapid computation owing to linealization of the non-linear term while solving the compartment model. The technique can generate not only MBF map but also k2 (washout) and blood volume (LV and RV) maps in the pixel-by-pixel manner. We evaluated the BFM by comparing with the conventional non-linear least squared technique. Methods [N-13]ammonia studies were performed on 10 normal volunteers (age: 30±9) under rest and stress (dipyridamole administration) conditions. For each PET (GEMINI GXL, Philips) acquisition, 185 MBq of [N-13]ammonia was injected and the scan duration was two minutes. The MBF maps under rest and stress were computed using the BFM. PMOD software was utilized as standard. In PMOD analysis, 17 regions were automatically segmented in the myocardial region. MBF and MFR values for each segment were computed, and compared with results of the BFM. Results The BFM showed 28% for the rest and 22% for the stress higher MBF values compared with the results from PMOD software, and 8% of underestimation of the BFM were observed for the MFR value. Significant correlations between two techniques (R>0.97) were revealed. Conclusions The method to generate parametric images of MBF, k2 and blood volume with [N-13]ammonia and PET was developed. The method generated functional maps computationally fast enough for clinical application