@article {Kasai2043, author = {Katsuhiko Kasai and Chietsugu Katoh and Keiichiro Yoshinaga and Osamu Manabe and Keiichi Magota and Nagara Tamaki}, title = {Development of automatic algorithm for quantification of oxidative metabolism in the right ventricular myocardium using 11C-acetate PET}, volume = {52}, number = {supplement 1}, pages = {2043--2043}, year = {2011}, publisher = {Society of Nuclear Medicine}, abstract = {2043 Objectives Increasing right ventricular (RV) oxidative metabolism may be associated with disease progression in heart failure and pulmonary hypertension (PH). Many imaging techniques have difficulty for evaluation of RV function because of anatomical varieties in RV. The purpose of the study was to develop an automatic algorithm for quantification of oxidative metabolism of the RV myocardium using 11C-acetate PET. Methods Twenty-nine patients with PH underwent 11C-acetate dynamic PET for 30min. Early-phase image and delayed-phase image were generated by summing first the 2min dynamic images and summing from 5-min to 10-min images, respectively. A 3-dimensional (3D) ROI, which covered whole RV and left ventricular (LV) myocardium, was automatically set on the early-phase image. In the 3D ROI, structures of the LV wall and the liver were eliminated. The contour of the RV wall was automatically extracted on the delayed-phase image, a time-activity curve in the RV wall was generated. Clearance rate of acetate (Auto-Kmono) in the RV wall was calculated by mono-exponential fitting from 5-min to 30-min images. RV wall ROI was manually set on the delayed-phase images, Kmono in the RV wall (Manual-Kmono) was calculated. To assess the stability of the new automatic algorithm, Auto-Kmono and Manual-Kmono in the RV wall were derived by two operators for each patient. Results Auto-Kmono yielded significantly correlated values with Manual-Kmono (r=0.980, p\<0.01, Auto-Kmono = 1.00 x Manual-Kmono - 0.001). Repeatability within inter-operator in Auto-Kmono (r=0.998) was significantly higher than those in Manual-Kmono (r=0.966) (n=29, p\<0.01). Conclusions We developed an automatic algorithm for quantification of oxidative metabolism of the RV myocardium using 11C-acetate PET. The new program dedicated more stable Kmono in the RV wall than the conventional manual method. Our new automatic method may be clinically useful to access the severity of pulmonary hypertension}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/52/supplement_1/2043}, eprint = {https://jnm.snmjournals.org/content}, journal = {Journal of Nuclear Medicine} }