RT Journal Article
SR Electronic
T1 Visualization of the trends of F-18 FDG uptake
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1975
OP 1975
VO 52
IS supplement 1
A1 Tomoka Kitao
A1 Hiroaki Kurihara
A1 Akira Hirayama
A1 Kenta Hiroi
A1 Yuzuru Kono
A1 Hideaki Kitamura
A1 Kiyoyuki Kodama
A1 Yusuke Miyamoto
A1 Yasuaki Arai
YR 2011
UL http://jnm.snmjournals.org/content/52/supplement_1/1975.abstract
AB 1975 Objectives The SUV has been widely used for the evaluation of F-18 FDG uptake on PET study, but it does not show the trends of the FDG uptake. Dynamic PET scan could be one way for the evaluation of the trend, but still dynamic PET scan is not feasible in routine clinical use because of its long scan time. We have demonstrated the apparent k-value (AKV) could be a tolerable index of the trend of the FDG uptake for the clinical use in elsewhere. In this presentation, we describe the sequential 3-timepoint PET scanning within 30minutes for calculating the AKV and display the transaxial map image of the calculated AKV. Methods Several cancer patients were performed 1 hour dynamic FDG PET/CT scanning, and followed by sequential 3-timepoint PET scanning. The sequential 3-timepoint PET scanning included acquisitions of 1 bed position of interest, multi-bed positions of whole body, and 1bed position of interest again. The acquisition times varied 2 to 10 minutes so that the total PET scan could be completed within 30 minutes. After image reconstruction, the clearance of F-18 FDG uptake, which called k-value, of the tumor was calculated from 1 hour dynamic PET data using Patlak-plot analysis, and also, the apparent k-value (AKV) of the tumor was calculated from the data of sequential 3-timepoint PET and the SUVmax of Aorta at the uptake time of 50 minutes (SUV50-Ao) as an arterial input function for Patlak-plot analysis. The AKV of the tumor was compared with the k-value. The AKV are calculated pixel by pixel and demonstrated transaxially as AKV map images. Results The k-value and the AKV of the lung tumor varied from 0.0026 to 0.08, and 0.0033 to 0.083 (min-1), respectively. The calculated AKV and the k-value showed strong correlation (r2=0.99). The AKV map image revealed the area of FDG increasing and not increasing (figure). Conclusions The trends of the FDG uptake could be evaluated by the sequential 3-timepoint PET scan within 30 minutes acquisition. The calculated AKV map image may provide another aspect of the FDG uptake for the clinical use