TY - JOUR T1 - Usefulness of dynamic FDG PET/CT for the evaluation of liver tumor JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 2099 LP - 2099 VL - 52 IS - supplement 1 AU - Shingo Baba AU - Koichiro Abe AU - Hirofumi Sawamoto AU - Yoshitaka Tanabe AU - Yasuhiro Maruoka AU - Masayuki Sasaki AU - Hiroshi Honda Y1 - 2011/05/01 UR - http://jnm.snmjournals.org/content/52/supplement_1/2099.abstract N2 - 2099 Objectives Low signal to noise ratio is one of the major cause of false negative in detecting lesions with FDG-PET/CT in the liver. High-contrast resolution is important to pick up the lesions out of physiological liver uptake. We have evaluated the usefulness of short-time dynamic PET scan of the liver adding to conventional whole body scan. Methods Twenty minutes dynamic data was recorded with list mode acquisition after conventional whole body PET/CT scan. Patients with various liver malignancies (53 cases 72 lesions: metastatic liver tumor: 28, HCC; 18, CCC; 7) were incorporated. Signal to noise ratio (SNR), Tumor to liver ratio (TLR), detectability of the lesions of 20 minutes integrated images were compared with conventional PET image including delayed scan(n=15). Images of FDG time rate of change over 20 minutes (TRC) was also calculated using dynamic data (10 flames of 2minutes). Results Additional 20min-scan improved the SNR 49% on average over conventional scan (P<0.001) and TLR was significantly increased (p<0.01). With this scan, additional liver lesions were detected in 21% (11/52) of the cases that were undetectable with conventional scan. TRC images also had higher detectability than conventional scan. Additional scan was useful especially in detecting liver metastasis from colon cancer and pancreas cancer. On the other hands, usefulness was limited in most of HCC cases that have same accumulation level with normal liver. Conclusions This simple method significantly improves the detectability and useful for various liver malignancies except for HCCs without substantial extension of the overall examination time ER -