RT Journal Article SR Electronic T1 Optimal scan duration of dynamic PET and feasibility of simplified quantification method for [11C]sertraline in human brain JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1186 OP 1186 VO 52 IS supplement 1 A1 Ji Who Kim A1 Jae Sung Lee A1 Su Jin Kim A1 Lathika Hoigebazar A1 Hak Jeong Lee A1 Kwang-Hee Shin A1 Kyung-Sang Yu A1 Wonsik Ahn A1 Jae Jeong A1 Dong Soo Lee YR 2011 UL http://jnm.snmjournals.org/content/52/supplement_1/1186.abstract AB 1186 Objectives Sertraline hydrochloride is a widely used selective serotonin reuptake inhibitor (SSRI). Previously, we developed [11C]sertraline to establish the PET microdosing study paradigm, and showed that single-tissue compartment model was suitable for its kinetic modeling studies. The aim of this study was to determine the optimal scan duration of dynamic PET studies for the accurate estimation of kinetic parameters and the feasibility of semi-quantitative approach without arterial blood sampling for the assessment of distribution volume ratio (DVR) in human brain. Methods Dynamic PET (duration: 90~120 min) imaging of [11C]sertraline and 3D T1 SPGR MRI scans were performed in 5 healthy male volunteers (mean age 32.4 y). During the PET scans, arterial blood samples were collected. Tissue time-activity curves were obtained from 7 brain regions, including putamen and cerebellum, using MRI. Total distribution volume (DV=K1/ k2) for each ROI and distribution volume ratio (DVR) relative to cerebellum were calculated using the single-tissue compartment model. In addition, ratio between the SUV of each ROI and that of cerebellum (SUVr) was computed and correlated with the DVR. Results Regional DV distribution estimated using single-tissue compartment model was concordant with the known density of serotonin transporters. Although most subjects showed relatively consistent DV values after 50 min scan duration, one subject showed much overestimated DV values before 40 min. SUVr with the integration of scan time of 50~90 min was well correlated with the DVR that was estimated using the arterial blood samples (r=0.98, SUVr = 0.76 DVR + 0.18). Conclusions Dynamic PET scan time longer than 50 min was required for the accurate estimation of DV of [11C]sertraline in normal human brain. In addition, SUVr (50~90 min) was the feasible simplified quantitative parameter reflecting the DVR of this tracer