%0 Journal Article %A Ji Who Kim %A Jae Sung Lee %A Su Jin Kim %A Lathika Hoigebazar %A Hak Jeong Lee %A Kwang-Hee Shin %A Kyung-Sang Yu %A Wonsik Ahn %A Jae Jeong %A Dong Soo Lee %T Optimal scan duration of dynamic PET and feasibility of simplified quantification method for [11C]sertraline in human brain %D 2011 %J Journal of Nuclear Medicine %P 1186-1186 %V 52 %N supplement 1 %X 1186 Objectives Sertraline hydrochloride is a widely used selective serotonin reuptake inhibitor (SSRI). Previously, we developed [11C]sertraline to establish the PET microdosing study paradigm, and showed that single-tissue compartment model was suitable for its kinetic modeling studies. The aim of this study was to determine the optimal scan duration of dynamic PET studies for the accurate estimation of kinetic parameters and the feasibility of semi-quantitative approach without arterial blood sampling for the assessment of distribution volume ratio (DVR) in human brain. Methods Dynamic PET (duration: 90~120 min) imaging of [11C]sertraline and 3D T1 SPGR MRI scans were performed in 5 healthy male volunteers (mean age 32.4 y). During the PET scans, arterial blood samples were collected. Tissue time-activity curves were obtained from 7 brain regions, including putamen and cerebellum, using MRI. Total distribution volume (DV=K1/ k2) for each ROI and distribution volume ratio (DVR) relative to cerebellum were calculated using the single-tissue compartment model. In addition, ratio between the SUV of each ROI and that of cerebellum (SUVr) was computed and correlated with the DVR. Results Regional DV distribution estimated using single-tissue compartment model was concordant with the known density of serotonin transporters. Although most subjects showed relatively consistent DV values after 50 min scan duration, one subject showed much overestimated DV values before 40 min. SUVr with the integration of scan time of 50~90 min was well correlated with the DVR that was estimated using the arterial blood samples (r=0.98, SUVr = 0.76 DVR + 0.18). Conclusions Dynamic PET scan time longer than 50 min was required for the accurate estimation of DV of [11C]sertraline in normal human brain. In addition, SUVr (50~90 min) was the feasible simplified quantitative parameter reflecting the DVR of this tracer %U