RT Journal Article
SR Electronic
T1 A new technique for the evaluation of both glucose metabolism and atrophy using brain FDG-PET alone
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1972
OP 1972
VO 52
IS supplement 1
A1 Hiroshi Matsuda
A1 Etsuko Imabayashi
A1 Ichiei Kuji
A1 Akira Seto
A1 Yasumasa Shimano
YR 2011
UL http://jnm.snmjournals.org/content/52/supplement_1/1972.abstract
AB 1972 Objectives Partial volume effects in atrophied areas should be taken into account when interpreting brain fluorodeoxyglucose positron emission tomography (FDG-PET) images of neurodegenerative diseases. To evaluate both glucose metabolism and atrophy using brain FDG-PET alone, we developed a new technique by application of tensor-based morphometry (TBM) originally used in three-dimensional volume data of magnetic resonance imaging (MRI) to FDG-PET. Methods After linear spatial normalization of brain FDG-PET to a Talairach space, high-dimension-warping was done using an original brain FDG-PET template. Contraction map images calculated from Jacobian determinants and spatially normalized FDG-PET images using this high-dimension-warping were obtained in 17 aged healthy volunteers (42 to 71 years old) using statistical parametric mapping (SPM2) as normal database for atrophy and brain glucose metabolism respectively. We compared atrophy and glucose metabolism images in a demented patient with mean and SD images of normal database using voxel-by-voxel Z score analysis. This comparison for atrophy and glucose metabolism was also performed in voxel-based morphometry of MRI data and conventionally warped FDG-PET images respectively. Results This new technique demonstrated similar results in local atrophy to voxel-based morphometry of MRI data. Statistically significant correlation coefficients over 0.6 were obtained in Z-score values between PET-based atrophy and MRI-based atrophy. Higher significance for decreased glucose metabolism in these areas was obtained in high-dimension-warping than in conventional warping maybe due to sufficient spatial normalization to a template in high-dimensional warping of severely atrophied areas. Conclusions The present new technique applying TBM to brain FDG-PET gives information on both glucose metabolism and atrophy at the same time and thereby enhancing the role of brain FDG-PET in clinical studies of neurodegenerative diseases