RT Journal Article
SR Electronic
T1 Near-infrared optical imaging of lymphatic function in inflammation
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1379
OP 1379
VO 52
IS supplement 1
A1 Aldrich, Melissa
A1 Hall, Mary
A1 Robinson, Holly
A1 Angermiller, Bonnie
A1 Sevick, Eva
YR 2011
UL http://jnm.snmjournals.org/content/52/supplement_1/1379.abstract
AB 1379 Objectives The human body contains approximately 12 liters of lymph, yet little is known of lymphatic flow changes that mediate infection, inflammation, or injury. Near-infrared (NIR) optical imaging affords the unique opportunity to observe effects on lymphatic function of inflammation and other system stresses. Methods In this study, mice were administered an inflammatory agent, and lymphatic function was visualized with NIR optical imaging utilizing indocyanine green, a NIR fluorophore. Results Systemic lymphatic propulsive flow velocity and propulsive frequency decreased dramatically in collecting lymphatic vessels at 4-24 hours after inflammatory insult, and gradually increased to normal levels after 7 days. Conclusions NIR imaging of lymphatic flow and pulsatile changes may enable rapid evaluation of therapies, as well as assessment of inflammatory status and infection state. Research Support DARPA-BAA08-2