PT  - JOURNAL ARTICLE
AU  - Tsutomu Zeniya
AU  - Tomonori Sakimoto
AU  - Kenji Ishida
AU  - Yoshiyuki Hirano
AU  - Hiroshi Watabe
AU  - Antti Sohlberg
AU  - Kotaro Minato
AU  - Hidehiro Iida
TI  - Evaluation of a new image reconstruction for high resolution and quantification in I-123 brain SPECT
DP  - 2010 May 01
TA  - Journal of Nuclear Medicine
PG  - 1344--1344
VI  - 51
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/51/supplement_2/1344.short
4100  - http://jnm.snmjournals.org/content/51/supplement_2/1344.full
SO  - J Nucl Med2010 May 01; 51
AB  - 1344 Objectives Quantitative SPECT studies with I-123-IMP are carried out for cerebral blood flow (CBF) at 110 institutions in Japan. High resolution is required in studies with I-123-IMZ for evaluating neuronal damage. We developed a new reconstruction method for high resolution and quantification. This study was aimed at evaluating performance of this reconstruction method in I-123 brain SPECT. Here, we performed a series of physical phantom studies and multicenter study. Methods This OSEM reconstruction method incorporates attenuation correction (AC), Monte-Carlo based scatter correction (SC) and collimator-detector response correction (CDRC). For I-123, especially, septal penetration correction (SPC) is done by convolution subtraction. A series of phantom studies with I-123 were performed by Toshiba GCA7200A with LEHR parallel-hole collimator. Multiple-line source phantom was scanned to measure spatial resolution. Uniformity was evaluated using cylindrical and pyramid phantoms. A realistic 3D brain phantom was scanned to evaluate quantitative accuracy. The brain phantom was also for testing reproducibility among different SPECT systems installed at different institutions. Results The CDRC significantly improved resolution from 9 mm to 5 mm. The reconstructed image of cylindrical and pyramid phantoms were almost visually uniform. The pyramid and brain phantoms showed the septal penetration was successfully corrected and the radioactive concentration was reproduced. Especially the image of brain phantom demonstrated high resolution, high quantitation and high S/N ratio. SPECT images were almost consistent among different SPECT systems installed at different institutions. Conclusions These phantom studies showed that our reconstruction method provides quantitative image with high resolution for I-123 SPECT, and suggested that the reconstructed image does not depend on system and institution