RT Journal Article
SR Electronic
T1 Multicenter evaluation of a quantitative SPECT reconstruction program using a realistic brain phantom
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1346
OP 1346
VO 51
IS supplement 2
A1 Hidehiro Iida
A1 Masaaki Takahashi
A1 Etsuko Imabayashi
A1 Kenji Ishida
A1 Tsutomu Zeniya
A1 Hiroshi Matsuda
YR 2010
UL http://jnm.snmjournals.org/content/51/supplement_2/1346.abstract
AB 1346 Objectives QSPECT is an academic software developed based on a series of previous publications, and provides quantitative images for commercial SPECT cameras. The program is contributing to >8,000 scans a year at 120 institutions in Japan mostly on patients with CVD. This study was aimed at evaluating accuracy and inter-institutional reproducibility of SPECT images, by using recently developed a realistic 3-dimensional brain phantom. Methods The phantom simulates head structure with bone and trachea spaces as well as detailed grey matter structure. The phantom was scanned using 8 SPECT scanners at 7 institutions, 4 cameras from 3 different manufacturers fitted with different collimator sets. Images were reconstructed by QSPECT, and also by the program from each manufacturer. SPM5 was used for atligning images to the original design, and their accuracy and inter-equipment variation was evaluated. Results The QSPECT yielded images which well agreed with digital data at all institutions, but with different image resolution, largely due to difference of the intrinsic performance of collimator. After smoothing with 15 mm Gaussian filter, images became consistent. Statistical analysis resulted in 10% variation of regional values relative to global mean in cortical and deep grey matter structures, except for cerebellum (14%) and parietal lob (13%) regions. This was caused by the institute-dependent head-rest structure/material, as well as the limitation in detecting the head contour. The images reconstructed at each SPECT camera, on the other hand, showed variations greater than QSPECT, namely 24% in cortex regions, 15% in cerebellum, 19% deep grey matter structure, and 19% in parietal lob region. Conclusions After compensation of attenuation and scatter, SPECT can provide images accurate and consistent among different SPECT systems installed in different institutions, which is advantageous for multicenter clinical studies