PT  - JOURNAL ARTICLE
AU  - Maddahi, Jamshid
AU  - Hansen, Christopher
AU  - Moody, Jonathan
AU  - Ficaro, Edward
AU  - Mendez, Ricardo
AU  - Bai, Chuanyong
AU  - Babla, Hetal
AU  - Conwell, Richard
AU  - Old, Rex
TI  - Quantitation of upright SPECT myocardial perfusion imaging: Multi-center development of a normal database and validation for evaluation of coronary artery disease
DP  - 2011 May 01
TA  - Journal of Nuclear Medicine
PG  - 1167--1167
VI  - 52
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/52/supplement_1/1167.short
4100  - http://jnm.snmjournals.org/content/52/supplement_1/1167.full
SO  - J Nucl Med2011 May 01; 52
AB  - 1167 Objectives In this multi-center study we developed a quantitative approach to interpretation of upright SPECT myocardial perfusion imaging (MPI) for overall detection of coronary artery disease (CAD) and detection of CAD in the left anterior descending (LAD), left circumflex (LCX) and right coronary (RCA) arteries. Methods A total of 445 patients (pts) underwent rest-stress Tc-99m labeled upright SPECT MPI using a triple head solid-state camera. There were 227 males and 218 females (age=60±13 yrs). 279 pts had a low pre-test likelihood of CAD (LL) and 166 underwent coronary angiography, of whom 109 had CAD (≥50% stenosis). Gender specific normal quantitative databases were developed from 88/279 LL pts (38 males and 50 females, age=52±10 yrs). SPECT images of the remaining 357 Pts were quantitatively analyzed using Corridor4DM software. Stress Polar maps were compared to the corresponding normal databases to determine the presence, size and location of perfusion defects. ROC curves were generated based on the quantitative defect extent and severity, using different defect thresholds (SD’s below the mean normal myocardial count distribution) using ROCKIT software package, and areas under the ROC curves (AUC) were calculated. Optimum defect thresholds were found based on the maximum AUC. Results Results for optimum AUC, sensitivity, specificity, and normalcy rate (in prospective LL Pts) are shown in the following Table: Conclusions A quantitative method for interpretation of upright SPECT MPI has been developed that allows objective detection and localization of coronary artery disease. Research Support Digirad Corporatio