RT Journal Article
SR Electronic
T1 Venous versus arterial blood samples for plasma input pharmacokinetic analysis of different radiotracer PET studies
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1974
OP 1974
VO 52
IS supplement 1
A1 Henri Greuter
A1 Mark Lubberink
A1 N. Harry Hendrikse
A1 Astrid van der Veldt
A1 Yeun Wong
A1 Robert Schuit
A1 Albert Windhorst
A1 Ronald Boellaard
A1 Adriaan Lammertsma
YR 2011
UL http://jnm.snmjournals.org/content/52/supplement_1/1974.abstract
AB 1974 Objectives Full quantitative analysis of dynamic PET studies often requires a metabolite corrected arterial plasma input function. A whole blood input function can be obtained either by online arterial sampling or from an image derived input function (IDIF). Next, data from several manual arterial blood samples are used to correct for changing plasma to blood (P/B) activity concentration (AC) ratios and parent fractions (PF). Use of venous blood samples is more patient friendly especially in case of an IDIF. The purpose of this study was to validate the use of venous blood samples to generate a metabolite corrected plasma IDIF. Methods During several PET studies with different tracers (see table) both arterial and venous manual blood samples were taken at different time points (n= 3 to 7 per study). Both sets of samples were used to measure blood and plasma ACs, P/B ratios and, if necessary, PFs. Venous data were compared with arterial data using linear regression analysis. Results During several PET studies with different tracers (see table) both arterial and venous manual blood samples were taken at different time points (n= 3 to 7 per study). Both sets of samples were used to measure blood and plasma ACs, P/B ratios and, if necessary, PFs. Venous data were compared with arterial data using linear regression analysis. Conclusions Manual arterial samples cannot be replaced by venous sampling without proper validation. Use of venous sampling to correct IDIFs for P/B ratios and PFs may be valid for some tracers