PT  - JOURNAL ARTICLE
AU  - Lee, Yukyung
AU  - Hwnag, Kyunghoon
AU  - Lee, Minkyung
AU  - Lee, Haejun
TI  - The role of thyroid scintigraphy in the management of patients with suspected congenital hypothyroidism
DP  - 2011 May 01
TA  - Journal of Nuclear Medicine
PG  - 1397--1397
VI  - 52
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/52/supplement_1/1397.short
4100  - http://jnm.snmjournals.org/content/52/supplement_1/1397.full
SO  - J Nucl Med2011 May 01; 52
AB  - 1397 Objectives Severe cases of congenital hypothyroidism suffer from permanent damage of intelligence.Hence, early diagnosis and prediction of prognosis are important for appropriate hormone treatment.The aim of present study was to investigate the role of thyroid scan in the management of patients with suspected congenital hypothyroidism. Methods We investigated medical records and thyroid scan images of 255 children with elevated serum TSH level or clinically suspicious of hypothyroidism retrospectively.All were above 7 days old, performed Tc-99m TcO4 scan. Interpretation of the images was performed by 2 nuclear medicine physicians. The results were divided into 5 groups. A group:well-visualization,Intense uptake B group:thyroid visualization in situ,within normal limit C group:Mild/faint/poor/decreased uptake D group:non-visualization of thyroid in situ E group:Ligual thyroid. Results Among finally enrolled patients of 252 children(3 patients were lost follow up),an image interpretation was as the followings. A group was 23,B group was 122,C group was 93,D group was 11,and E group was 3 respectively.Based on OPD medical record of 252 patients, we divided them into 3 groups as transient hypothyroidism group(who stopped hormone treatment as normalization of serum TSH),young under-the care group(under 3 yrs old on hormone therapy),and permanent hypothyroidism group(over 3 yrs old on hormone therapy).Twelve patients with permanent hypothyroidism were of 2 patients from group A,3 from B,3 from C,2 from D,and 2 from E. Except for lingual thyroid, the highest percentage of permanent hypothyroidism was D group(18.2%),and followed by A group(8.7%),C group(3.2%)and B group(2.5%). Conclusions According to our results, not only D group(non-visualization of thyroid in situ, suspicious of thyroid aplasia/ hypoplasia) but also A group(showing intense uptake) showed high percentage of final diagnosis of permanent hypothyroidism.These results may be helpful in management of the patients with suspected congenital hypothyroidism.Further studies including more patient warranted