RT Journal Article
SR Electronic
T1 68Ga-Citrate PET/CT in patents with inflammatory/infectious disease
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 368
OP 368
VO 51
IS supplement 2
A1 Nanni, Cristina
A1 Allegri, Vincenzo
A1 Fantini, Lorenzo
A1 Ambrosini, Valentina
A1 Montini, Gian Carlo
A1 Castellucci, Paolo
A1 Rizzello, Anna
A1 Rubello, Domenico
A1 Pettinato, Cinzia
A1 Fanti, Stefano
YR 2010
UL http://jnm.snmjournals.org/content/51/supplement_2/368.abstract
AB 368 Objectives 67Ga-citrate has been used in the diagnostic of inflammatory-infectious diseases. Although accurate,67Ga-citrate scintigraphy presents some practical disadvantages.Ga68 is a positron emitting isotope for PET diagnostics with short half life, high-energy photons, high spatial resolution, low costs, low dosimetry and a short time procedure. To preliminary evaluate the accuracy of 68Ga-citrate PET/CT imaging in inflammatory-infectious diseases. Methods This study was approved by our local Ethical Committee. 38 pts (mean age 50) were enrolled, for a total of 47 scans. 8 had a suspected discitis, 25 osteomyelitis, 3 IBD, 2 other diseases (1 FUO (fever of unknown origin) 1 myocardial sarcoidosis). 9pts underwent also a post therapy scan. Each pt underwent a 68Ga-citrate PET/CT(GE Discovery LS or STE). PET images were interpreted considering clinical data. Both visual and semi-quantitative (SUV max) assessment was performed. PET results were compared to WBC scintigraphy, MR and histopathology (when possible) within 2 weeks and clinical follow up. Results The image quality was high for each pt. 17/47 scans were negative and 30/47 were positive with mean SUV max 4,4. Among the negative PET, 3pts had a discal degeneration, 10 were studied after an effective treatment, 1 had an eosinophilic granuloma, 1 a FUO and 1 a myocardial sarcoidosis (small lesions). Among the positive PET we found three false positive results represented by 2 bone lymphomas and an osteoblastoma, whose diagnosis was reached only after biopsy (MR was positive for OM as well). Overall, we found 27 TP, 15 TN, 3 FP and 2 FN scans, giving respectively: sensitivity 93%, specificity 83%, PPV 90%, NPV 88%, accuracy 89%. Conclusions Although preliminary, these data confirm the possible 68Ga-citrate role for diagnosis of bone infections, especially in consideration of its very favourable characteristics. However, more studied are required, including a comparison population evaluated with the more standard FDG