RT Journal Article
SR Electronic
T1 Three hours after injection of 18F-fluoro-2-deoxy-D-glucose is optimal for imaging atherosclerosis in carotid arteries with positron emission tomography
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1708
OP 1708
VO 51
IS supplement 2
A1 Oh, Minyoung
A1 Kim, Ji Young
A1 Park, Seol Hoon
A1 Ryu, Jin-Sook
A1 Kim, Jae Seung
A1 Oh, Seung Jun
A1 Im, Ki Chun
A1 Kang, Dong-Wha
A1 Moon, Dae Hyuk
YR 2010
UL http://jnm.snmjournals.org/content/51/supplement_2/1708.abstract
AB 1708 Objectives We investigated the optimal imaging time after injection of 18F-fluoro-2-deoxy-D-glucose(FDG) to measure atherosclerosis in carotid arteries with positron emission tomography/computed tomography (PET/CT). Methods The study subjects were 12 patients who have had recent symptomatic plaques in their carotid arteries. For carotid plague imaging, we underwent FDG-PET/CT imaging at 2 hr in five and at 3 hr in seven patients after FDG injection. Vessel wall uptake were measured using the maximal standardized uptake value (maxSUV) and, mean and maximal blood normalized standardized uptake value (target-to-background ratio, TBR) of the symptomatic carotid arteries. Blood pool activity was measured as mean SUV of superior vena cava (SVC) and jugular vein in these patients as well as age and sex matched 14 patients who underwent whole body FDG-PET/CT examinations 1 hr after FDG injection as a routine follow-up schedule. Results FDG-PET/CT revealed visible FDG uptake in all patients with symptomatic carotid plaque. There were no difference of maxSUV between 2 hr and 3 hr groups (2.62±0.45 vs. 3.00±0.85, P = 0.335). However, maximal and mean TBR values that were normalized to blood pool activity in SVC were different significantly (2.04±0.22 vs. 3.54±0.62, P<0.05; 1.65±0.15 vs. 2.70±0.42, P < 0.05, respectively). TBR normalized to jugular vein activity also showed the same difference (P < 0.05). Blood pool activity in SVC and jugular vein showed a time-dependent decrease in SUV values (SUV normalized for SVC at 1, 2 and 3 hr: 1.18±0.15, 0.85±0.05 and 0.56±0.10, P < 0.05; SUV normalized for jugular vein: 1.04±0.16, 0.79±0.03 and 0.66±0.04, P < 0.05). Conclusions Our results suggest that imaging at 3 hr after 18F-FDG injection may be optimal to assess atherosclerosis in carotid arteries as it shows higher TBR and lower blood pool activity