RT Journal Article
SR Electronic
T1 Is there a correlation between tumor proliferative and glycolytic phenotype in high grade soft tissue sarcoma?
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1278
OP 1278
VO 51
IS supplement 2
A1 Spick, Claudio
A1 Czernin, Johannes
A1 Auerbach, Martin
A1 Tap, William
A1 Dry, Sarah
A1 Walter, Franziska
A1 Phelps, Michael
A1 Eilber, Fritz
A1 Benz, Matthias
YR 2010
UL http://jnm.snmjournals.org/content/51/supplement_2/1278.abstract
AB 1278 Objectives The aim of this study was to compare tumor proliferation - as estimated by FLT (18F-3`-deoxy-3`-fluorothymidine) - with the corresponding tumor glycolytic phenotype - measured by FDG (18F-2’-deoxy-2’-glucose) - in recently diagnosed high grade soft tissue sarcoma (STS) patients using positron emission tomography / computer tomography (PET/CT). Methods From October 2008 to April 2009, 12 patients (5 men, 7 women; mean age, 62 years [range, 30-94]) with biopsy proven STS underwent 18F-FLT-PET/CT and 18F-FDG-PET/CT imaging before the initiation of neoadjuvant therapy. The patient population included MPNST (n=3), Leiomyosarcoma (n=2), GIST (n=2), NOS (n=2), Liposarcoma (n=1), Angiosarcoma (n=1), and Fibromyxoidsarcoma (n=1). The tumor size and the peak standardized uptake value for FLT (FLT-SUVpeak) and FDG (FDG-SUVpeak) was measured. Linear regression analysis was used to correlate the tumor FDG and FLT uptake. Results Mean tumor size averaged 9.1±4.2 cm (range, 5.1-18.0 cm). FDG-SUVpeak averaged 7.2±4.3 g/ml (median, 6.1 g/ml; range, 2.8-16.9 g/ml), which was not significantly different compared to the FLT-SUVpeak (mean, 7.0±4.0 g/ml; median, 6.9 g/ml; range, 2.1-16.1 g/ml) (p=0.95). Linear regression analysis indicated no significant correlation between FDG-SUVpeak and FLT-SUVpeak (Pearson Correlation Coefficient, 0.50; p=0.10). FDG uptake was increased in 7 and decreased in 5 patients compared to the FLT uptake. Conclusions These data suggest that FDG- and FLT-PET imaging are equally well suited to detect and characterize soft tissue sarcomas. However, tumor proliferation as estimated by FLT PET did not correlate with the tumor glycolytic phenotype measured by FDG-PET. The reasons for this finding await further clarification